The generation of neurons in the adult mammalian brain requires the activation of quiescent
neural stem cells (NSCs). This activation and the sequential steps of neuron formation from …

Reactive oxygen species are produced by all aerobic cells and are widely believed to play a
pivotal role in aging as well as a number of degenerative diseases. The consequences of …

The cytoplasmic focal adhesion protein-tyrosine kinase (FAK) localizes with surface integrin
receptors at sites where cells attach to the extracellular matrix. Increased FAK tyrosine …

I. Overview T HE general characterization of the growth hormone/insulin-like growth factor-I
(GH/IGF-I) system has been established for a considerable length of time, and we will not …

In mammals, insulin is the principal hormone controlling blood glucose and acts by
stimulating glucose influx and metabolism in muscle and adipocytes and inhibiting …

In the present work, we demonstrate that treatment with 1, 25-dihydroxyvitamin D3 for 24
hours increased in a dose-dependent manner the levels of the two major insulin receptor …

The 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (3β-HSD) isoenzymes are
responsible for the oxidation and isomerization of Δ5-3β-hydroxysteroid precursors into Δ4 …

Both insulin resistance and hyperinsulinemia have been reported to be independent risk
factors for cardiovascular diseases. However, little is known regarding insulin signaling in …

I. Introduction IN THE fasted state, glucose homeostasis depends upon the balance between
hepatic glucose production and glucose utilization by the major insulin-dependent tissues …

We analyzed the binding site (s) for Grb2 on the epidermal growth factor (EGF) receptor
(EGFR), using cell lines overexpressing EGFRs containing various point and deletion …