Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …

Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …

Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant
expansion and proliferation of macrophages around injured sensory neurons in dorsal root …

Microglia, the CNS-resident immune cells, play important roles in disease, but the spectrum
of their possible activation states is not well understood. We derived co-regulated gene …

Acute pain is protective and a cardinal feature of inflammation. Chronic pain after arthritis,
nerve injury, cancer, and chemotherapy is associated with chronic neuroinflammation, a …

Microglia, resident macrophages of the CNS, are essential to brain development,
homeostasis, and disease. Microglial activation and proliferation are hallmarks of many CNS …

In rheumatology, chronic pain most often sets in after a musculoskeletal injury. Its
persistence is not always due to the progression of the initial injury, but in some cases to the …

Nerve growth factor (NGF) antagonism is on the verge of becoming a powerful analgesic
treatment for numerous conditions, including osteoarthritis and lower back pain. This review …

Spinal long-term potentiation (LTP) at C-fiber synapses is hypothesized to underlie chronic
pain. However, a causal link between spinal LTP and chronic pain is still lacking. Here, we …

Central sensitization caused by spinal disinhibition is a key mechanism of mechanical
allodynia in neuropathic pain. However, the molecular mechanisms underlying spinal …