The Hippo pathway and human cancer
The Hippo pathway controls organ size in diverse species, whereas pathway deregulation
can induce tumours in model organisms and occurs in a broad range of human carcinomas …
can induce tumours in model organisms and occurs in a broad range of human carcinomas …
Mammalian Krüppel-like factors in health and diseases
BB McConnell, VW Yang - Physiological reviews, 2010 - journals.physiology.org
The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …
processes that include proliferation, differentiation, growth, development, survival, and …
LPA receptors: subtypes and biological actions
Lysophosphatidic acid (LPA) is a small, ubiquitous phospholipid that acts as an extracellular
signaling molecule by binding to and activating at least five known G protein–coupled …
signaling molecule by binding to and activating at least five known G protein–coupled …
Updating Phospholipase A2 Biology
M Murakami, H Sato, Y Taketomi - Biomolecules, 2020 - mdpi.com
The phospholipase A2 (PLA2) superfamily contains more than 50 enzymes in mammals that
are subdivided into several distinct families on a structural and biochemical basis. In …
are subdivided into several distinct families on a structural and biochemical basis. In …
Nrf2 signaling pathway in chemoprotection and doxorubicin resistance: potential application in drug discovery
Doxorubicin (DOX) is extensively applied in cancer therapy due to its efficacy in suppressing
cancer progression and inducing apoptosis. After its discovery, this chemotherapeutic agent …
cancer progression and inducing apoptosis. After its discovery, this chemotherapeutic agent …
S100A8/A9 activate key genes and pathways in colon tumor progression
M Ichikawa, R Williams, L Wang, T Vogl… - Molecular cancer …, 2011 - AACR
The tumor microenvironment plays an important role in modulating tumor progression.
Earlier, we showed that S100A8/A9 proteins secreted by myeloid-derived suppressor cells …
Earlier, we showed that S100A8/A9 proteins secreted by myeloid-derived suppressor cells …
Structural basis of substrate discrimination and integrin binding by autotaxin
J Hausmann, S Kamtekar, E Christodoulou… - Nature structural & …, 2011 - nature.com
Autotaxin (ATX, also known as ectonucleotide pyrophosphatase/phosphodiesterase-2,
ENPP2) is a secreted lysophospholipase D that generates the lipid mediator …
ENPP2) is a secreted lysophospholipase D that generates the lipid mediator …
Lysophospholipids and their receptors in the central nervous system
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), two of the best-studied
lysophospholipids, are known to influence diverse biological events, including organismal …
lysophospholipids, are known to influence diverse biological events, including organismal …
Autotaxin and LPA receptor signaling in cancer
AJS Houben, WH Moolenaar - Cancer and Metastasis Reviews, 2011 - Springer
Lysophosphatidic acid (LPA; monoacyl-glycerol-3-phosphate) is a lipid mediator that
functions as a mitogen and motility factor for many cell types. LPA signals through six …
functions as a mitogen and motility factor for many cell types. LPA signals through six …
Autotaxin—an LPA producing enzyme with diverse functions
K Nakanaga, K Hama, J Aoki - The journal of biochemistry, 2010 - academic.oup.com
Autotaxin (ATX) is an ecto-enzyme responsible for lysophosphatidic acid (LPA) production in
blood. ATX is present in various biological fluids such as cerebrospinal and seminal fluids …
blood. ATX is present in various biological fluids such as cerebrospinal and seminal fluids …