Biomaterial-driven in situ cardiovascular tissue engineering—a multi-disciplinary perspective

TB Wissing, V Bonito, CVC Bouten… - NPJ Regenerative …, 2017 - nature.com
There is a persistent and growing clinical need for readily-available substitutes for heart
valves and small-diameter blood vessels. In situ tissue engineering is emerging as a …

Endothelial progenitor cells and integrins: adhesive needs

F Caiado, S Dias - Fibrogenesis & tissue repair, 2012 - Springer
In the last decade there have been multiple studies concerning the contribution of
endothelial progenitor cells (EPCs) to new vessel formation in different physiological and …

Shear stress: An essential driver of endothelial progenitor cells

AG Kutikhin, MY Sinitsky, AE Yuzhalin… - Journal of Molecular and …, 2018 - Elsevier
The blood flow through vessels produces a tangential, or shear, stress sensed by their
innermost layer (ie, endothelium) and representing a major hemodynamic force. In humans …

Capture of endothelial cells under flow using immobilized vascular endothelial growth factor

RJ Smith Jr, MT Koobatian, A Shahini, DD Swartz… - Biomaterials, 2015 - Elsevier
We demonstrate the ability of immobilized vascular endothelial growth factor (VEGF) to
capture endothelial cells (EC) with high specificity under fluid flow. To this end, we …

Enhancing Mesenchymal Stromal Cell Potency: Inflammatory Licensing via Mechanotransduction

MA Skibber, SD Olson, KS Prabhakara, BS Gill… - Frontiers in …, 2022 - frontiersin.org
Mesenchymal stromal cells (MSC) undergo functional maturation upon their migration from
bone marrow and introduction to a site of injury. This inflammatory licensing leads to …

Parallel-plate flow chamber and continuous flow circuit to evaluate endothelial progenitor cells under laminar flow shear stress

WO Lane, AE Jantzen, TA Carlon… - Journal of …, 2012 - pmc.ncbi.nlm.nih.gov
The overall goal of this method is to describe a technique to subject adherent cells to
laminar flow conditions and evaluate their response to well quantifiable fluid shear …

Impact of REDV peptide density and its linker structure on the capture, movement, and adhesion of flowing endothelial progenitor cells in microfluidic devices

A Mahara, K Kitagawa, A Otaka, T Nakaoki… - Materials Science and …, 2021 - Elsevier
Ligand-immobilization to stents and vascular grafts is expected to promote
endothelialization by capturing flowing endothelial progenitor cells (EPCs). However, the …

Endothelial colony forming cell rolling and adhesion supported by peptide-grafted hydrogels

Y Tian, WJ Seeto, MA Páez-Arias, MS Hahn, EA Lipke - Acta Biomaterialia, 2022 - Elsevier
The aim of this study was to investigate the ability of peptides and peptide combinations to
support circulating endothelial colony forming cell (ECFC) rolling and adhesion under shear …

Peptide-grafted poly (ethylene glycol) hydrogels support dynamic adhesion of endothelial progenitor cells

WJ Seeto, Y Tian, EA Lipke - Acta biomaterialia, 2013 - Elsevier
This study investigated the dynamic adhesion of endothelial progenitor cells (EPCs) to
peptide-grafted poly (ethylene glycol) diacrylate (PEGDA) hydrogels and determined the …

Effect of cyclic uniaxial mechanical strain on endothelial progenitor cell differentiation

P Ravishankar, I Tandon, K Balachandran - … Engineering and Technology, 2022 - Springer
Abstract Purpose Endothelial progenitor cells (EPCs) have been used as an autologous or
allogeneic source in multiple tissue engineering applications. EPCs possess high …