Publisher Summary This chapter discusses the need for multivariate analysis in biophysical
studies, presents the way principal components analysis (PCA) can be implemented in the …

In recent years, more 3D protein structures have become available, which has made the
analysis of large molecular structures much easier. There is a strong demand for geometric …

Background There is a considerable literature on the source of the thermostability of proteins
from thermophilic organisms. Understanding the mechanisms for this thermostability would …

Alternative splicing is thought to be one of the major sources for functional diversity in higher
eukaryotes. Interestingly, when map** splicing events onto protein structures, about half of …

Nucleosomes form the fundamental building blocks of chromatin. Subtle modifications of the
constituent histone tails mediate chromatin stability and regulate gene expression. For this …

The emergence of polypeptide catalysts for amino acid activation, the slowest step in protein
synthesis, poses a significant puzzle associated with the origin of biology. This problem is …

Background Because amino acid activation is rate-limiting for uncatalyzed protein synthesis,
it is a key puzzle in understanding the origin of the genetic code. Two unrelated classes (I …

The role of aminoacyl-tRNA synthetases (aaRS) in the emergence and evolution of genetic
coding poses challenging questions concerning their provenance. We seek evidence about …

Vorolign, a fast and flexible structural alignment method for two or more protein structures is
introduced. The method aligns protein structures using double dynamic programming and …

How Nature discovered genetic coding is a largely ignored question, yet the answer is key to
explaining the transition from biochemical building blocks to life. Other, related puzzles also …