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Effector-triggered immunity
The innate immune system detects pathogens via germline-encoded receptors that bind to
conserved pathogen ligands called pathogen-associated molecular patterns (PAMPs). Here …
conserved pathogen ligands called pathogen-associated molecular patterns (PAMPs). Here …
Conservation and similarity of bacterial and eukaryotic innate immunity
Pathogens are ubiquitous and a constant threat to their hosts, which has led to the evolution
of sophisticated immune systems in bacteria, archaea and eukaryotes. Bacterial immune …
of sophisticated immune systems in bacteria, archaea and eukaryotes. Bacterial immune …
Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes
INTRODUCTION Detection of pathogens by the innate immune system is an essential first
step in successful host defense against infection. Pathogens are typically detected by …
step in successful host defense against infection. Pathogens are typically detected by …
Legionnaires' Disease: State of the Art Knowledge of Pathogenesis Mechanisms of Legionella
S Mondino, S Schmidt, M Rolando… - Annual Review of …, 2020 - annualreviews.org
Legionella species are environmental gram-negative bacteria able to cause a severe form of
pneumonia in humans known as Legionnaires' disease. Since the identification of …
pneumonia in humans known as Legionnaires' disease. Since the identification of …
The gut microbiota of insects–diversity in structure and function
Insect guts present distinctive environments for microbial colonization, and bacteria in the
gut potentially provide many beneficial services to their hosts. Insects display a wide range …
gut potentially provide many beneficial services to their hosts. Insects display a wide range …
Ubiquitination independent of E1 and E2 enzymes by bacterial effectors
Signalling by ubiquitination regulates virtually every cellular process in eukaryotes. Covalent
attachment of ubiquitin to a substrate is catalysed by the E1, E2 and E3 three-enzyme …
attachment of ubiquitin to a substrate is catalysed by the E1, E2 and E3 three-enzyme …
Pathogenicity and Virulence of Legionella: Intracellular replication and host response
Bacteria of the genus Legionella are natural pathogens of amoebae that can cause a severe
pneumonia in humans called Legionnaires' Disease. Human disease results from inhalation …
pneumonia in humans called Legionnaires' Disease. Human disease results from inhalation …
Legionella and Coxiella effectors: strength in diversity and activity
Legionella pneumophila and Coxiella burnetii are two evolutionarily related intracellular
pathogens that use the Dot/Icm type IV secretion system to translocate effectors into host …
pathogens that use the Dot/Icm type IV secretion system to translocate effectors into host …
Genomic analysis of 38 Legionella species identifies large and diverse effector repertoires
Infection by the human pathogen Legionella pneumophila relies on the translocation of∼
300 virulence proteins, termed effectors, which manipulate host cell processes. However …
300 virulence proteins, termed effectors, which manipulate host cell processes. However …
Pathogenesis of acute stroke and the role of inflammasomes
Inflammation is an innate immune response to infection or tissue damage that is designed to
limit harm to the host, but contributes significantly to ischemic brain injury following stroke …
limit harm to the host, but contributes significantly to ischemic brain injury following stroke …