Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression in
the immune system. Studies have shown that lncRNAs are expressed in a highly lineage …

Methylation of RNA occurs at a variety of atoms, nucleotides, sequences and tertiary
structures. Strongly related to other posttranscriptional modifications, methylation of different …

The ribosomal RNA of the human protein synthesis machinery comprises numerous
chemical modifications that are introduced during ribosome biogenesis. Here we present the …

RNA modifications such as m6A methylation form an additional layer of complexity in the
transcriptome. Nanopore direct RNA sequencing can capture this information in the raw …

Following synthesis, tRNAs are peppered by numerous chemical modifications which may
differentially affect a tRNA's structure and function. Although modifications affecting the …

Cellular senescence is characterized by a decrease in protein synthesis, although the
underlying processes are mostly unclear. Chemical modifications to transfer RNAs (tRNAs) …

Functional tRNA molecules always contain a wide variety of post-transcriptionally modified
nucleosides. These modifications stabilize tRNA structure, allow for proper interaction with …

The regulation of gene expression in response to stress is an essential cellular protection
mechanism. Recent advances in tRNA modification analysis and genome-based codon bias …

More than 140 post-transcriptional modifications (PTMs) are known to decorate cellular
RNAs, but their incidence, identity and significance in viral RNA are still largely unknown …

The field of RNA modifications, so-called epitranscriptomics, has flourished over the past
years owing to improvements of detection methods and the identification of important …