Gene regulation in the immune system by long noncoding RNAs
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression in
the immune system. Studies have shown that lncRNAs are expressed in a highly lineage …
the immune system. Studies have shown that lncRNAs are expressed in a highly lineage …
7-Methylguanosine modifications in transfer RNA (tRNA)
C Tomikawa - International journal of molecular sciences, 2018 - mdpi.com
More than 90 different modified nucleosides have been identified in tRNA. Among the tRNA
modifications, the 7-methylguanosine (m7G) modification is found widely in eubacteria …
modifications, the 7-methylguanosine (m7G) modification is found widely in eubacteria …
Detection of m6A from direct RNA sequencing using a multiple instance learning framework
RNA modifications such as m6A methylation form an additional layer of complexity in the
transcriptome. Nanopore direct RNA sequencing can capture this information in the raw …
transcriptome. Nanopore direct RNA sequencing can capture this information in the raw …
RNA nucleotide methylation
Methylation of RNA occurs at a variety of atoms, nucleotides, sequences and tertiary
structures. Strongly related to other posttranscriptional modifications, methylation of different …
structures. Strongly related to other posttranscriptional modifications, methylation of different …
Transfer RNA modifications: nature's combinatorial chemistry playground
JE Jackman, JD Alfonzo - Wiley Interdisciplinary Reviews: RNA, 2013 - Wiley Online Library
Following synthesis, tRNAs are peppered by numerous chemical modifications which may
differentially affect a tRNA's structure and function. Although modifications affecting the …
differentially affect a tRNA's structure and function. Although modifications affecting the …
Perturbation of METTL1-mediated tRNA N7- methylguanosine modification induces senescence and aging
Y Fu, F Jiang, X Zhang, Y Pan, R Xu, X Liang… - Nature …, 2024 - nature.com
Cellular senescence is characterized by a decrease in protein synthesis, although the
underlying processes are mostly unclear. Chemical modifications to transfer RNAs (tRNAs) …
underlying processes are mostly unclear. Chemical modifications to transfer RNAs (tRNAs) …
Distribution and frequencies of post-transcriptional modifications in tRNAs
Functional tRNA molecules always contain a wide variety of post-transcriptionally modified
nucleosides. These modifications stabilize tRNA structure, allow for proper interaction with …
nucleosides. These modifications stabilize tRNA structure, allow for proper interaction with …
[HTML][HTML] tRNA modifications regulate translation during cellular stress
The regulation of gene expression in response to stress is an essential cellular protection
mechanism. Recent advances in tRNA modification analysis and genome-based codon bias …
mechanism. Recent advances in tRNA modification analysis and genome-based codon bias …
Positive-sense RNA viruses reveal the complexity and dynamics of the cellular and viral epitranscriptomes during infection
W McIntyre, R Netzband, G Bonenfant… - Nucleic Acids …, 2018 - academic.oup.com
More than 140 post-transcriptional modifications (PTMs) are known to decorate cellular
RNAs, but their incidence, identity and significance in viral RNA are still largely unknown …
RNAs, but their incidence, identity and significance in viral RNA are still largely unknown …
Mechanistic insights into m6A RNA enzymes
T Lence, C Paolantoni, L Worpenberg… - Biochimica et Biophysica …, 2019 - Elsevier
The field of RNA modifications, so-called epitranscriptomics, has flourished over the past
years owing to improvements of detection methods and the identification of important …
years owing to improvements of detection methods and the identification of important …