Cardiac endothelium–myocyte interaction: clinical opportunities for new heart failure therapies regardless of ejection fraction
Heart failure (HF) is an important global health problem with great socioeconomic burden.
Outcomes remain sub-optimal. Endothelium–cardiomyocyte interactions play essential roles …
Outcomes remain sub-optimal. Endothelium–cardiomyocyte interactions play essential roles …
International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family …
Abstract Relaxin, insulin-like peptide 3 (INSL3), relaxin-3, and INSL5 are the cognate
ligands for the relaxin family peptide (RXFP) receptors 1–4, respectively. RXFP1 activates …
ligands for the relaxin family peptide (RXFP) receptors 1–4, respectively. RXFP1 activates …
Statement on pregnancy in pulmonary hypertension from the Pulmonary Vascular Research Institute
AR Hemnes, DG Kiely, BA Cockrill… - Pulmonary …, 2015 - journals.sagepub.com
Pregnancy outcomes in patients with pulmonary hypertension remain poor despite
advanced therapies. Although consensus guidelines recommend against pregnancy in …
advanced therapies. Although consensus guidelines recommend against pregnancy in …
Sex-specific effects of a high fat diet on aortic inflammation and dysfunction
Obesity and vascular dysfunction are independent and sexually dimorphic risk factors for
cardiovascular disease. A high fat diet (HFD) is often used to model obesity in mice, but the …
cardiovascular disease. A high fat diet (HFD) is often used to model obesity in mice, but the …
Reperfusion therapy with recombinant human relaxin-2 (Serelaxin) attenuates myocardial infarct size and NLRP3 inflammasome following ischemia/reperfusion injury …
J Valle Raleigh, AG Mauro… - Cardiovascular …, 2017 - academic.oup.com
Aims The preconditioning-like infarct-sparing and anti-inflammatory effects of the peptide
hormone relaxin following ischemic injury have been studied in the heart. Whether …
hormone relaxin following ischemic injury have been studied in the heart. Whether …
Vascular actions of relaxin: nitric oxide and beyond
The peptide hormone relaxin regulates the essential maternal haemodynamic adaptations
in early pregnancy through direct actions on the renal and systemic vasculature. These …
in early pregnancy through direct actions on the renal and systemic vasculature. These …
The actions of relaxin on the human cardiovascular system
M Sarwar, XJ Du, TB Dschietzig… - British Journal of …, 2017 - Wiley Online Library
The insulin‐like peptide relaxin, originally identified as a hormone of pregnancy, is now
known to exert a range of pleiotropic effects including vasodilatory, anti‐fibrotic, angiogenic …
known to exert a range of pleiotropic effects including vasodilatory, anti‐fibrotic, angiogenic …
Green extraction of orange peel waste reduces TNFα-induced vascular inflammation and endothelial dysfunction
Orange peel waste (OPW) is known to contain an abundant amount of polyphenols
compounds such as flavonoids, well-reported for their antioxidant and anti-inflammatory …
compounds such as flavonoids, well-reported for their antioxidant and anti-inflammatory …
[HTML][HTML] Relaxin elicits renoprotective actions accompanied by increasing bile acid levels in streptozotocin-induced diabetic mice
Background The peptide hormone relaxin has potent anti-fibrotic and anti-inflammatory
properties in various organs, including the kidneys. However, the protective effects of relaxin …
properties in various organs, including the kidneys. However, the protective effects of relaxin …
Serelaxin‐mediated signal transduction in human vascular cells: bell‐shaped concentration–response curves reflect differential coupling to G proteins
Background and Purpose In a recently conducted phase III clinical trial, RELAX‐AHF,
serelaxin infusion over 48 h improved short‐and long‐term clinical outcomes in patients with …
serelaxin infusion over 48 h improved short‐and long‐term clinical outcomes in patients with …