The microenvironment (local environment), including viscosity, temperature, polarity,
hypoxia, and acidic-basic status (pH), plays indispensable roles in cellular processes …

Intramolecular Charge Transfer (ICT) is a crucial photophysical phenomenon that can be
used to improve the Stokes' shift in fluorescent dyes. The introduction of molecular …

Fluorescent probes have long been valuable tools in the study of biological systems. With
the ever-expanding range of known enzymatic biomarkers for disease, it has never been …

Highly sensitive and high‐accuracy detection of biomolecular changes is vital for the early
diagnosis and treatment of diverse diseases. Due to their unique advantages and the broad …

Fluorogenic probes, small-molecule sensors that unmask brilliant fluorescence upon
exposure to specific stimuli, are powerful tools for chemical biology. Those probes that …

Peroxynitrite (ONOO–), an important reactive oxygen species (ROS), may be generated in
the mitochondria under various physiological and pathological conditions. In this work, we …

Hypoxia plays crucial roles in many diseases and is a central target for them. Present
hypoxia imaging is restricted to the covalent approach, which needs tedious synthesis. In …

In the past few years, the preparation of novel small-molecule fluorescent probes for specific
detection and imaging of chemical species inside lysosomes has attracted considerable …

A new dual-function fluorescent probe is developed for detecting nitroreductase (NTR) and
adenosine triphosphate (ATP) with different responses. Imaging application of the probe …

As one of the most representative hypoxic enzymes, nitroreductases (NTRs) play
momentous roles in malignant tumor progression, metastasis, invasion and angiogenesis …