Obtaining genetics insights from deep learning via explainable artificial intelligence
Artificial intelligence (AI) models based on deep learning now represent the state of the art
for making functional predictions in genomics research. However, the underlying basis on …
for making functional predictions in genomics research. However, the underlying basis on …
Recent advances in droplet microfluidics for single-cell analysis
Single-cell manipulation and analysis is essential for studying many fundamental biological
processes and discovering cellular heterogeneity. Multi-parameter studies of intercellular …
processes and discovering cellular heterogeneity. Multi-parameter studies of intercellular …
[HTML][HTML] A single-cell atlas of chromatin accessibility in the human genome
Current catalogs of regulatory sequences in the human genome are still incomplete and lack
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …
Epigenetic patterns in a complete human genome
The completion of a telomere-to-telomere human reference genome, T2T-CHM13, has
resolved complex regions of the genome, including repetitive and homologous regions …
resolved complex regions of the genome, including repetitive and homologous regions …
[HTML][HTML] Single cell cancer epigenetics
M Casado-Pelaez, A Bueno-Costa, M Esteller - Trends in Cancer, 2022 - cell.com
Bulk sequencing methodologies have allowed us to make great progress in cancer
research. Unfortunately, these techniques lack the resolution to fully unravel the epigenetic …
research. Unfortunately, these techniques lack the resolution to fully unravel the epigenetic …
NK cells are never alone: crosstalk and communication in tumour microenvironments
Y Zhou, L Cheng, L Liu, X Li - Molecular Cancer, 2023 - Springer
Immune escape is a hallmark of cancer. The dynamic and heterogeneous tumour
microenvironment (TME) causes insufficient infiltration and poor efficacy of natural killer (NK) …
microenvironment (TME) causes insufficient infiltration and poor efficacy of natural killer (NK) …
[HTML][HTML] Cell fate decisions, transcription factors and signaling during early retinal development
The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …
Metformin, macrophage dysfunction and atherosclerosis
Metformin is one of the most widely prescribed hypoglycemic drugs and has the potential to
treat many diseases. More and more evidence shows that metformin can regulate the …
treat many diseases. More and more evidence shows that metformin can regulate the …
Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity
X Shi, Y Li, Q Yuan, S Tang, S Guo, Y Zhang… - Nature …, 2022 - nature.com
Chromatin accessibility plays an essential role in controlling cellular identity and the
therapeutic response of human cancers. However, the chromatin accessibility landscape …
therapeutic response of human cancers. However, the chromatin accessibility landscape …
Loop-extrusion and polymer phase-separation can co-exist at the single-molecule level to shape chromatin folding
Loop-extrusion and phase-separation have been proposed as mechanisms that shape
chromosome spatial organization. It is unclear, however, how they perform relative to each …
chromosome spatial organization. It is unclear, however, how they perform relative to each …