The BLAST programs are widely used tools for searching protein and DNA databases for
sequence similarities. For protein comparisons, a variety of definitional, algorithmic and …

The purpose of this article is to provide a brief history of the development and application of
computer algorithms for the analysis and prediction of DNA binding sites. This problem can …

Probabilistic models are becoming increasingly important in analysing the huge amount of
data being produced by large-scale DNA-sequencing efforts such as the Human Genome …

The idea for this book came from the time the authors spent at the Statistics and Applied
Mathematical Sciences Institute (SAMSI) in Research Triangle Park in North Carolina …

This book provides a self-contained and up-to-date treatment of the Monte Carlo method
and develops a common framework under which various Monte Carlo techniques can be" …

A wealth of protein and DNA sequence data is being generated by genome projects and
other sequencing efforts. A crucial barrier to deciphering these sequences and …

MOTIVATION: Molecular biologists frequently can obtain interesting insight by aligning a set
of related DNA, RNA or protein sequences. Such alignments can be used to determine …

Optimized weight matrices defining four major eukaryotic promoter elements, the TATA-box,
cap signal, CCAAT-, and GC-box, are presented; they were derived by comparative …

Proteins interact with genomic DNA to bring the genome to life; and these interactions also
define many functional features of the genome. SBF and MBF are sequence-specific …

Protein sequence alignments have become an important tool for molecular biologists. Local
alignments are frequently constructed with the aid of a “substitution score matrix” that …