Targeted protein degradation (TPD) provides unprecedented opportunities for drug
discovery. While the proteolysis-targeting chimera (PROTAC) technology has already …

After 20 years of sometimes quiet growth, fragment-based drug discovery (FBDD) has
become mainstream. More than 30 drug candidates derived from fragments have entered …

Epidemiological studies have indicated an association between statin use and reduced
incidence of colorectal cancer (CRC), and work in preclinical models has demonstrated a …

The phytohormone auxin triggers transcriptional reprogramming through a well-
characterized perception machinery in the nucleus. By contrast, mechanisms that underlie …

Responsible for the ongoing coronavirus disease 19 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells through binding of the …

MicroScale Thermophoresis (MST) is a powerful technique to quantify biomolecular
interactions. It is based on thermophoresis, the directed movement of molecules in a …

Aptamers are single-stranded oligonucleotides that bind to their targets via specific structural
interactions. To improve the properties and performance of aptamers, modified nucleotides …

The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has created global health and
economic emergencies. SARS-CoV-2 viruses promote their own spread and virulence by …

The emergence of biopolymer building blocks is a crucial step during the origins of life,,,,–.
However, all known formation pathways rely on rare pure feedstocks and demand …

The unfolded protein response (UPR) adjusts the cell's protein folding capacity in the
endoplasmic reticulum (ER) according to need. IRE1 is the most conserved UPR sensor in …