Nitric oxide (NO) is a gaseous molecule that has a central role in signaling pathways
involved in numerous physiological processes (eg, vasodilation, neurotransmission …

The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian
cells and serves to regulate a multitude of physiological processes has continued to …

Heart failure (HF) is considered as a severe health problem worldwide, while cardiac fibrosis
is one of the main driving factors for the progress of HF. Cardiac fibrosis was characterized …

Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

Nitric oxide (NO) from endothelial NO synthase importantly contributes to vascular
homeostasis. Reduced NO production or increased scavenging during disease conditions …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Swynghedauw, Bernard. Molecular Mechanisms of Myocardial Remodeling. Physiol. Rev.
79: 215–262, 1999.—“Remodeling” implies changes that result in rearrangement of …

Experimental work during the past 15 years has demonstrated that endothelial cells in the
heart play an obligatory role in regulating and maintaining cardiac function, in particular, at …

TNFα is crucially involved in the pathogenesis and progression of atherosclerosis,
myocardial ischemia/reperfusion injury and heart failure. The formation and release of TNFα …

Since its discovery as a biologically active molecule in the late 1980s, nitric oxide (NO) has
been found to play an important role as signal molecule in many parts of the organism as …