Bone is a richly vascularized connective tissue. As the main source of oxygen, nutrients,
hormones, neurotransmitters and growth factors delivered to the bone cells, vasculature is …

Recent advances in cell tracing and sequencing technologies have expanded our
knowledge on leukocyte behavior. As a consequence, inflammatory cells, such as monocyte …

Background Macrophages are tissue resident immune cells important for host defence and
homeostasis. During diabetes, macrophages and other innate immune cells are known to …

The importance of the vascular supply for bone is well-known to orthopaedists but is still
rather overlooked within the wider field of skeletal research. Blood supplies oxygen …

Diabetes microangiopathy, a hallmark complication of diabetes, is characterised by
structural and functional abnormalities within the intricate network of microvessels beyond …

The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide, especially as a
result of our aging society, high caloric intake and sedentary lifestyle. Besides the well …

Abstract Purpose of Review Diabetes mellitus is defined by elevated blood glucose levels
caused by changes in glucose metabolism and, according to its pathogenesis, is classified …

Bone is a highly vascularized tissue, although this aspect of bone is often overlooked. In this
article, the importance of blood flow in bone repair and regeneration will be reviewed. First …

Abstract Type 2 diabetes (T2D) is associated with numerous complications, including
increased risk of fragility fractures, despite seemingly protective factors [eg, normal bone …

Randomized, cross-sectional, and prospective studies have demonstrated that
microvascular complications in patients with diabetes are not only the cause of blindness …