Cardiovascular disease is the leading cause of morbidity and mortality worldwide.
Advancing age is a major risk factor for develo** cardiovascular disease because of the …

Obesity‐induced insulin resistance and type 2 diabetes mellitus can ultimately result in
various complications, including diabetic cardiomyopathy. In this case, cardiac dysfunction is …

The mitochondria of various tissues from mice, naked mole rats (NMRs), and bats possess
two mechanistically similar systems to prevent the generation of mitochondrial reactive …

Metabolism plays an important role in regulating aging at several levels, and metabolic
reprogramming is the main driving force of aging. Due to the different metabolic needs of …

Translation of cardioprotective interventions aimed at reducing myocardial injury during
ischaemia–reperfusion from experimental studies to clinical practice is an important yet …

The incidence of diastolic dysfunction increases with age in both humans and mice. This is
characterized by increased passive stiffness and slower relaxation of the left ventricle. The …

Senescence is related to the loss of cellular homeostasis and functions, which leads to a
progressive decline in physiological ability and to aging-associated diseases. Since …

Aging shows a decline in overall physical function, and cellular senescence is the powerful
catalyst leading to aging. Considering that aging will be accompanied with the emergence of …

In recent decades, there have been several models describing the relationships between
the cytoskeleton and the bioenergetic function of the cell. The main player in these models is …

Mitochondria perform a central role in life and death of the eukaryotic cell. They are major
players in the generation of macroergic compounds and function as integrated signaling …