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Phylogenetic and phylodynamic approaches to understanding and combating the early SARS-CoV-2 pandemic
Determining the transmissibility, prevalence and patterns of movement of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is central to our understanding …
respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is central to our understanding …
Progress and challenges in virus genomic epidemiology
Genomic epidemiology, which links pathogen genomes with associated metadata to
understand disease transmission, has become a key component of outbreak response …
understand disease transmission, has become a key component of outbreak response …
[HTML][HTML] Real-time genomic surveillance for enhanced control of infectious diseases and antimicrobial resistance
This article advocates for mobilizing pathogen genomic surveillance to contain and mitigate
health threats from infectious diseases and antimicrobial resistance (AMR), building upon …
health threats from infectious diseases and antimicrobial resistance (AMR), building upon …
Closed-loop insulin delivery versus sensor-augmented pump therapy in older adults with type 1 diabetes (ORACL): a randomized, crossover trial
OBJECTIVE To assess the efficacy and safety of closed-loop insulin delivery compared with
sensor-augmented pump therapy among older adults with type 1 diabetes. RESEARCH …
sensor-augmented pump therapy among older adults with type 1 diabetes. RESEARCH …
SARS-CoV-2 mouse adaptation selects virulence mutations that cause TNF-driven age-dependent severe disease with human correlates
The diversity of COVID-19 disease in otherwise healthy people, from seemingly
asymptomatic infection to severe life-threatening disease, is not clearly understood. We …
asymptomatic infection to severe life-threatening disease, is not clearly understood. We …
Platform for isolation and characterization of SARS-CoV-2 variants enables rapid characterization of Omicron in Australia
Genetically distinct variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) have emerged since the start of the COVID-19 pandemic. Over this period, we developed …
2) have emerged since the start of the COVID-19 pandemic. Over this period, we developed …
SARS-CoV-2 Omicron: evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern
Genetically distinct viral variants of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) have been recorded since January 2020. Over this time global vaccine programs …
CoV-2) have been recorded since January 2020. Over this time global vaccine programs …
AusTrakka: fast-tracking nationalized genomics surveillance in response to the COVID-19 pandemic
T Hoang, AG da Silva, AV Jennison… - Nature …, 2022 - nature.com
The COVID-19 pandemic has driven demand for integrated genomics, resulting in fast-
tracked development of AusTrakka, Australia's pathogen genomics platform. This facilitated …
tracked development of AusTrakka, Australia's pathogen genomics platform. This facilitated …
SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity
Respiratory tract infection with SARS-CoV-2 results in varying immunopathology underlying
COVID-19. We examine cellular, humoral and cytokine responses covering 382 immune …
COVID-19. We examine cellular, humoral and cytokine responses covering 382 immune …
Multi-site implementation of whole genome sequencing for hospital infection control: a prospective genomic epidemiological analysis
Background Current microbiological methods lack the resolution to accurately identify
multidrug-resistant organism (MDRO) transmission, however, whole genome sequencing …
multidrug-resistant organism (MDRO) transmission, however, whole genome sequencing …