Chronic liver diseases such as nonalcoholic fatty liver disease (NAFLD) or viral hepatitis are
characterized by persistent inflammation and subsequent liver fibrosis. Liver fibrosis critically …

Functional cure of chronic hepatitis B (CHB)—or hepatitis B surface antigen (HBsAg) loss
after 24 weeks off therapy—is now the goal of treatment, but is rarely achieved with current …

Hepatitis B virus (HBV) is a non-cytopathic, hepatotropic virus with the potential to cause a
persistent infection, ultimately leading to cirrhosis and hepatocellular carcinoma. Over the …

Vaccines have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
morbidity and mortality, yet emerging variants challenge their effectiveness. The prevailing …

Resident memory T cells (TRM) form a distinct type of T memory cells that stably resides in
tissues. TRM form an integral part of the immune sensing network and have the ability to …

Gene therapy with adeno-associated virus (AAV) vectors has demonstrated safety and long-
term efficacy in a number of trials across target organs, including eye, liver, skeletal muscle …

Recombinant adeno-associated virus (rAAV) vectors are one of the most promising in vivo
gene delivery tools. Several features make rAAV vectors an ideal platform for gene transfer …

Clearance of apoptotic cells by macrophages prevents excessive inflammation and supports
immune tolerance. Here, we examined the effect of blocking apoptotic cell clearance on anti …

The liver is bathed in bacterial products, including lipopolysaccharide transported from the
intestinal portal vasculature, but maintains a state of tolerance that is exploited by persistent …

Chronic hepatitis B virus (HBV) infection affects 300 million patients worldwide,, in whom
virus-specific CD8 T cells by still ill-defined mechanisms lose their function and cannot …