Background Immune checkpoint blockade (ICB) has been approved for the treatment of
triple-negative breast cancer (TNBC), since it significantly improved the progression-free …

Disseminated cancer cells (DCCs) in secondary organs can remain dormant for years to
decades before reactivating into overt metastasis. Microenvironmental signals leading to …

Previous studies have indicated that microRNA (miR)‑210‑3p is upregulated in NSCLC,
however, the specific mechanism underlying the role of miR‑210‑3p in NSCLC …

Worldwide, metastasis is the leading cause of more than 90% of cancer-related deaths.
Currently, no specific therapies effectively impede metastasis. Metastatic processes are …

Recent work has established that SWI-independent-3 (SIN3) chromatin modification
complexes play key roles in cancer progression. We previously demonstrated that …

All-trans retinoic acid (atRA) regulates gene expression and is used to treat acute
promyelocytic leukemia. Attempts to use atRA in breast cancer without a stratification …

Vitamin A is an essential diet-derived nutrient that has biological activity affected through an
active metabolite, all-trans retinoic acid (atRA). Retinol-binding protein type 1 (RBP1) is an …

Retinoids are essential in balancing proliferation, differentiation and apoptosis, and they
exert their effects through retinoic acid receptors (RARs) and retinoid X receptors (RXRs) …

Disseminated cancer cells (DCCs) identified in secondary organs, sometimes before the
primary tumor becomes detectable and treated, can remain dormant for years to decades …

Abstract Cellular Retinol Binding Protein 1 (CRBP1) gene is a protein coding gene located
on human chromosome 3q21, which codifies a protein named CRBP1. CRBP1 is widely …