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The nucleolus as a multiphase liquid condensate
The nucleolus is the most prominent nuclear body and serves a fundamentally important
biological role as a site of ribonucleoprotein particle assembly, primarily dedicated to …
biological role as a site of ribonucleoprotein particle assembly, primarily dedicated to …
The role of 3D genome organization in development and cell differentiation
H Zheng, W ** 3D chromosome architecture
R Kempfer, A Pombo - Nature Reviews Genetics, 2020 - nature.com
Determining how chromosomes are positioned and folded within the nucleus is critical to
understanding the role of chromatin topology in gene regulation. Several methods are …
understanding the role of chromatin topology in gene regulation. Several methods are …
Diverse silent chromatin states modulate genome compartmentalization and loop extrusion barriers
The relationships between chromosomal compartmentalization, chromatin state and function
are poorly understood. Here by profiling long-range contact frequencies in HCT116 colon …
are poorly understood. Here by profiling long-range contact frequencies in HCT116 colon …
Ki-67: more than a proliferation marker
X Sun, PD Kaufman - Chromosoma, 2018 - Springer
Ki-67 protein has been widely used as a proliferation marker for human tumor cells for
decades. In recent studies, multiple molecular functions of this large protein have become …
decades. In recent studies, multiple molecular functions of this large protein have become …
Higher-order inter-chromosomal hubs shape 3D genome organization in the nucleus
Eukaryotic genomes are packaged into a 3-dimensional structure in the nucleus. Current
methods for studying genome-wide structure are based on proximity ligation. However, this …
methods for studying genome-wide structure are based on proximity ligation. However, this …
Atlas of subcellular RNA localization revealed by APEX-Seq
We introduce APEX-seq, a method for RNA sequencing based on direct proximity labeling of
RNA using the peroxidase enzyme APEX2. APEX-seq in nine distinct subcellular locales …
RNA using the peroxidase enzyme APEX2. APEX-seq in nine distinct subcellular locales …
Lamina-associated domains: links with chromosome architecture, heterochromatin, and gene repression
In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the
nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize …
nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize …
The 4D nucleome project
Abstract The 4D Nucleome Network aims to develop and apply approaches to map the
structure and dynamics of the human and mouse genomes in space and time with the goal …
structure and dynamics of the human and mouse genomes in space and time with the goal …
Lamina-associated domains: peripheral matters and internal affairs
At the nuclear periphery, associations of chromatin with the nuclear lamina through lamina-
associated domains (LADs) aid functional organization of the genome. We review the …
associated domains (LADs) aid functional organization of the genome. We review the …