Somatic mutations in aging, cancer and neurodegeneration
The somatic mutation theory of aging posits that the accumulation of mutations in the genetic
material of somatic cells as a function of time results in a decrease in cellular function. In …
material of somatic cells as a function of time results in a decrease in cellular function. In …
Can aging be programmed? A critical literature review
The evolution of the aging process has long been a biological riddle, because it is difficult to
explain the evolution of a trait that has apparently no benefit to the individual. Over 60 years …
explain the evolution of a trait that has apparently no benefit to the individual. Over 60 years …
Evolution of spatially structured host–parasite interactions
Spatial structure has dramatic effects on the demography and the evolution of species. A
large variety of theoretical models have attempted to understand how local dispersal may …
large variety of theoretical models have attempted to understand how local dispersal may …
Could aging evolve as a pathogen control strategy?
Aging is often attributed to the detrimental side effects of beneficial traits but not a
programmed adaptive process. Alternatively, the pathogen control hypothesis posits that …
programmed adaptive process. Alternatively, the pathogen control hypothesis posits that …
Physiological underpinnings in life-history trade-offs in man's most popular selection experiment: the dog
Animal life-history traits fall within a limited ecological space, a continuum referred to as a
“slow-fast” life-history axis. Differences of life-history traits are thought to result from trade …
“slow-fast” life-history axis. Differences of life-history traits are thought to result from trade …
Non-programmed versus programmed aging paradigm
G Libertini - Current aging science, 2015 - ingentaconnect.com
There are two opposite paradigms to explain aging, here precisely defined as “age-related
progressive mortality increase, ie fitness decline, in the wild”. The first maintains that natural …
progressive mortality increase, ie fitness decline, in the wild”. The first maintains that natural …
The essence of aging
The idea that aging is a purposeful, programmed series of events is intuitively appealing
based on its many conserved aspects and the demonstrated feasibility of modifying life span …
based on its many conserved aspects and the demonstrated feasibility of modifying life span …
Programmed life span in the context of evolvability
Population turnover is necessary for progressive evolution. In the context of a niche with
fixed carrying capacity, aging contributes to the rate of population turnover. Theoretically, a …
fixed carrying capacity, aging contributes to the rate of population turnover. Theoretically, a …
[HTML][HTML] How does the body know how old it is?
Based on the ideas of RA Fisher, neoDarwinism came to dominate evolutionary science in
the first half of the wentieth entury, and within that perspective aging could never be an …
the first half of the wentieth entury, and within that perspective aging could never be an …
Change and aging senescence as an adaptation
Understanding why we age is a long-lived open problem in evolutionary biology. Aging is
prejudicial to the individual, and evolutionary forces should prevent it, but many species …
prejudicial to the individual, and evolutionary forces should prevent it, but many species …