Cancer health disparities in racial/ethnic minorities in the United States
VA Zavala, PM Bracci, JM Carethers… - British journal of …, 2021 - nature.com
There are well-established disparities in cancer incidence and outcomes by race/ethnicity
that result from the interplay between structural, socioeconomic, socio-environmental …
that result from the interplay between structural, socioeconomic, socio-environmental …
[HTML][HTML] Advances in understanding the role of P-gp in doxorubicin resistance: Molecular pathways, therapeutic strategies, and prospects
Abstract P-glycoprotein (P-gp) is a drug efflux transporter that triggers doxorubicin (DOX)
resistance. In this review, we highlight the molecular avenues regulating P-gp, such as Nrf2 …
resistance. In this review, we highlight the molecular avenues regulating P-gp, such as Nrf2 …
[HTML][HTML] Management of patients with advanced prostate cancer: report of the advanced prostate cancer consensus conference 2019
Background Innovations in treatments, imaging, and molecular characterisation in advanced
prostate cancer have improved outcomes, but there are still many aspects of management …
prostate cancer have improved outcomes, but there are still many aspects of management …
A whole-genome reference panel of 14,393 individuals for East Asian populations accelerates discovery of rare functional variants
Underrepresentation of non-European (EUR) populations hinders growth of global precision
medicine. Resources such as imputation reference panels that match the study population …
medicine. Resources such as imputation reference panels that match the study population …
Prostate cancer racial disparities: a systematic review by the prostate cancer foundation panel
Abstract Context Prostate cancer (PCa) is a complex disease that disproportionately impacts
Black men in the USA. The structural factors that drive heterogeneous outcomes for patients …
Black men in the USA. The structural factors that drive heterogeneous outcomes for patients …
[HTML][HTML] African-specific molecular taxonomy of prostate cancer
Prostate cancer is characterized by considerable geo-ethnic disparity. African ancestry is a
significant risk factor, with mortality rates across sub-Saharan Africa of 2.7-fold higher than …
significant risk factor, with mortality rates across sub-Saharan Africa of 2.7-fold higher than …
Cellular and molecular mechanisms underlying prostate cancer development: therapeutic implications
Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …
Tumor sequencing of African ancestry reveals differences in clinically relevant alterations across common cancers
E Jiagge, DX **, JY Newberg, T Perea-Chamblee… - Cancer cell, 2023 - cell.com
Cancer genomes from patients with African (AFR) ancestry have been poorly studied in
clinical research. We leverage two large genomic cohorts to investigate the relationship …
clinical research. We leverage two large genomic cohorts to investigate the relationship …
Survival of African-American and Caucasian men after sipuleucel-T immunotherapy: outcomes from the PROCEED registry
Abstract Purpose African Americans experience greater prostate cancer risk and mortality
than do Caucasians. An analysis of pooled phase III data suggested differences in overall …
than do Caucasians. An analysis of pooled phase III data suggested differences in overall …
Integrative comparison of the genomic and transcriptomic landscape between prostate cancer patients of predominantly African or European genetic ancestry
Men of predominantly African Ancestry (AA) have higher prostate cancer (CaP) incidence
and worse survival than men of predominantly European Ancestry (EA). While …
and worse survival than men of predominantly European Ancestry (EA). While …