Clinical and technological advances promoting early hemorrhage control and physiologic
resuscitation as well as early diagnosis and optimal treatment of sepsis have significantly …

Summary Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS)
is a clinical endotype of chronic critical illness. PICS consists of a self-perpetuating cycle of …

Objectives: This study sought to examine mortality, health-related quality of life, and physical
function among sepsis survivors who developed chronic critical illness. Design: Single …

Background: Many sepsis survivors develop chronic critical illness (CCI) and are assumed
to be immunosuppressed, but there is limited clinical evidence to support this. We sought to …

Background Sarcopenia is a known risk factor for poor outcomes across many chronic
diseases. The impact on outcomes of both pre‐existing sarcopenia and acute muscle …

Objective: To analyze serial biomarkers of the persistent inflammation, immunosuppression,
and catabolism syndrome (PICS) to gain insight into the pathobiology of chronic critical …

BACKGROUND A growing number of patients survive sepsis but remain chronically critically
ill. We sought to define clinical outcomes and incidence of chronic critical illness (CCI) after …

Sepsis and trauma were the primary inciting events. With tremendous the advances in care
over the ensuing four decades, the epidemiology of MOF evolved from a fulminant …

As early as the 1990s, chronic critical illness, a distinct syndrome of persistent high-acuity
illness requiring management in the ICU, was reported under a variety of descriptive terms …

Objective: We sought to compare traditional inpatient outcomes to long-term functional
outcomes and mortality of surgical intensive care unit (SICU) patients with sepsis. Summary …