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[HTML][HTML] Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption: An UNGAP review
M Vertzoni, P Augustijns, M Grimm, M Koziolek… - European journal of …, 2019 - Elsevier
Oral administration is the most common route of drug delivery. The absorption of a drug from
the gut into the bloodstream involves disintegration of the solid dosage form, dissolution of …
the gut into the bloodstream involves disintegration of the solid dosage form, dissolution of …
Application of targeted mass spectrometry in bottom-up proteomics for systems biology research
The enormous diversity of proteoforms produces tremendous complexity within cellular
proteomes, facilitates intricate networks of molecular interactions, and constitutes a …
proteomes, facilitates intricate networks of molecular interactions, and constitutes a …
Non-uniformity of changes in drug-metabolizing enzymes and transporters in liver cirrhosis: implications for drug dosage adjustment
Liver cirrhosis is a chronic disease that affects the liver structure, protein expression, and
overall metabolic function. Abundance data for drug-metabolizing enzymes and transporters …
overall metabolic function. Abundance data for drug-metabolizing enzymes and transporters …
Large‐scale multiplex absolute protein quantification of drug‐metabolizing enzymes and transporters in human intestine, liver, and kidney microsomes by SWATH‐MS …
K Nakamura, M Hirayama‐Kurogi, S Ito, T Kuno… - …, 2016 - Wiley Online Library
The purpose of the present study was to examine simultaneously the absolute protein
amounts of 152 membrane and membrane‐associated proteins, including 30 metabolizing …
amounts of 152 membrane and membrane‐associated proteins, including 30 metabolizing …
Quantitative proteomics of clinically relevant drug-metabolizing enzymes and drug transporters and their intercorrelations in the human small intestine
The levels of drug-metabolizing enzymes (DMEs) and transporter proteins in the human
intestine are pertinent to determine oral drug bioavailability. Despite the paucity of reports on …
intestine are pertinent to determine oral drug bioavailability. Despite the paucity of reports on …
Oral drug absorption in pediatrics: the intestinal wall, its developmental changes and current tools for predictions
JM Nicolas, F Bouzom, C Hugues… - … & drug disposition, 2017 - Wiley Online Library
The dissolution, intestinal absorption and presystemic metabolism of a drug depend on its
physicochemical characteristics but also on numerous physiological (eg gastrointestinal pH …
physicochemical characteristics but also on numerous physiological (eg gastrointestinal pH …
Regional expression levels of drug transporters and metabolizing enzymes along the pig and human intestinal tract and comparison with Caco-2 cells
SFC Vaessen, MMH van Lipzig, RHH Pieters… - Drug metabolism and …, 2017 - Elsevier
Intestinal transporter proteins and metabolizing enzymes play a crucial role in the oral
absorption of a wide variety of drugs. The aim of the current study was to characterize better …
absorption of a wide variety of drugs. The aim of the current study was to characterize better …
Identification and quantification of blood–brain barrier transporters in isolated rat brain microvessels
The blood–brain barrier (BBB) maintains brain homeostasis by tightly regulating the
exchange of molecules with systemic circulation. It consists primarily of microvascular …
exchange of molecules with systemic circulation. It consists primarily of microvascular …
Quantitative atlas of cytochrome P450, UDP-glucuronosyltransferase, and transporter proteins in jejunum of morbidly obese subjects
Protein expression levels of drug-metabolizing enzymes and transporters in human jejunal
tissues excised from morbidly obese subjects during gastric bypass surgery were evaluated …
tissues excised from morbidly obese subjects during gastric bypass surgery were evaluated …
Critical issues and optimized practices in quantification of protein abundance level to determine interindividual variability in DMET proteins by LC‐MS/MS proteomics
Protein quantification data on drug metabolizing enzymes and transporters (collectively
referred as DMET proteins) in human tissues are useful in predicting interindividual …
referred as DMET proteins) in human tissues are useful in predicting interindividual …