Previous meta-analyses of structural MRI studies have shown diffuse cortical and sub-
cortical abnormalities in unipolar depression. However, the presence of duplicate …

As the population ages, the economic and societal impacts of neurodegenerative and
neuropsychiatric disorders are expected to rise sharply. Like dementia, late-life depressive …

Context Although differences in clinical characteristics exist between major depressive
disorder (MDD) and bipolar disorder (BD), consistent structural brain abnormalities that …

Importance Late-life depression (LLD) is characterized by considerable heterogeneity in
clinical manifestation. Unraveling such heterogeneity might aid in elucidating etiological …

BackgroundAbnormalities in cortico-striatal-pallidal-thalamic (CSPT) circuits have been
implicated in major depressive disorder (MDD). However, the robustness of these findings …

Objective We utilized the amyloid imaging ligand Pittsburgh Compound B (PiB) to determine
the presence of Alzheimer's disease (AD) pathology in different mild cognitive impairment …

Gray matter abnormalities within frontal–subcortical and limbic networks are hypothesized to
play a key role in the pathophysiology of late-life depression. In this work, gray matter …

Although cognitive and functional impairment are the hallmark features of Alzheimer's
disease (AD), neuropsychiatric symptoms associated with AD account for increased rates of …

Background We systematically reviewed and meta-analyzed the association of late-life
depression (LLD) with hippocampal volume (HCV) and total brain volume (TBV), and of …

Context Older patients with depression and executive dysfunction represent a population
with significant disability and a high likelihood of failing pharmacotherapy. Objectives To …