Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …

Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell
malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Members of the caspase family of proteases play essential roles in the initiation and
execution of apoptosis. These caspases are divided into two groups: the initiator caspases …

Cellular senescence refers to an irreversible state of cell-cycle arrest and plays important
roles in aging and cancer biology. Because senescence is associated with increased cell …

Aberrant chromosomal architecture, ranging from small insertions or deletions to large
chromosomal alterations, is one of the most common characteristics of cancer genomes …

Aneuploidy, a state of karyotype imbalance, is a hallmark of cancer. Changes in
chromosome copy number have been proposed to drive disease by modulating the dosage …

Whole-genome and centrosome duplication as a consequence of cytokinesis failure can
drive tumorigenesis in experimental model systems. However, whether cytokinesis failure is …

Chromosome segregation errors cause aneuploidy and genomic heterogeneity, which are
hallmarks of cancer in humans. A persistent high frequency of these errors (chromosomal …

Mitosis is a delicate event that must be executed with high fidelity to ensure genomic
stability. Recent work has provided insight into how mitotic errors shape cancer genomes by …