Aging is the strongest risk factor for metabolic, vascular and neurodegenerative diseases.
Aging alone is associated with a gradual decline of cognitive and motor functions …

Autism spectrum disorder (ASD) is an umbrella term encompassing several
neurodevelopmental disorders such as Asperger syndrome or autism. It is characterised by …

Slow inward currents (SICs) are known as excitatory events of neurons elicited by astrocytic
glutamate via activation of extrasynaptic NMDA receptors. By using slice electrophysiology …

Abstract Purpose Hypoparathyroidism (HypoPT) is a rare endocrine disease and
conventional therapy is based on calcium and vitamin D analogues. Conventional therapy …

Cellular senescence, a stable cell division arrest caused by severe damage and stress, is a
hallmark of aging in vertebrates including humans. With progressing age, senescent cells …

Astrocytes are key players in the regulation of brain development and function. They sense
and respond to the surrounding activity by elevating their intracellular calcium (Ca2+) levels …

Astrocytes generate robust intracellular Ca 2+ signals that are assumed to be key regulators
of astrocytic function. Among various Ca 2+ mobilization mechanisms, Ca 2+ release from …

The hippocampus, which provides cognitive functions, has been shown to become highly
vulnerable during aging. One important modulator of the hippocampal neural network is the …

Astrocytes are ubiquitous in the brain and spinal cord and display a complex morphology
important for the local interactions with neighboring cells, resulting in the modulation of …

Spinocerebellar ataxia type 3 (SCA3) is a rare neurodegenerative disease caused by an
abnormal polyglutamine expansion within the ataxin-3 protein (ATXN3). This leads to …