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Functionalizing DNA origami to investigate and interact with biological systems
DNA origami has emerged as a powerful method to generate DNA nanostructures with
dynamic properties and nanoscale control. These nanostructures enable complex …
dynamic properties and nanoscale control. These nanostructures enable complex …
Photocleavable Ortho-Nitrobenzyl-Protected DNA Architectures and Their Applications
This review article introduces mechanistic aspects and applications of photochemically
deprotected ortho-nitrobenzyl (ONB)-functionalized nucleic acids and their impact on …
deprotected ortho-nitrobenzyl (ONB)-functionalized nucleic acids and their impact on …
DNA origami: scaffolds for creating higher order structures
DNA has become one of the most extensively used molecular building blocks for
engineering self-assembling materials. DNA origami is a technique that uses hundreds of …
engineering self-assembling materials. DNA origami is a technique that uses hundreds of …
Biocatalytic cascades operating on macromolecular scaffolds and in confined environments
Biocatalytic cascades guide complex, efficient and selective intracellular transformations.
These unique features originate from the spatial organization of the biocatalysts in confined …
These unique features originate from the spatial organization of the biocatalysts in confined …
Building machines with DNA molecules
H Ramezani, H Dietz - Nature Reviews Genetics, 2020 - nature.com
In nature, DNA molecules carry the hereditary information. But DNA has physical and
chemical properties that make it attractive for uses beyond heredity. In this Review, we …
chemical properties that make it attractive for uses beyond heredity. In this Review, we …
A DNA origami‐based gene editing system for efficient gene therapy in vivo
W Tang, T Tong, H Wang, X Lu, C Yang… - Angewandte Chemie …, 2023 - Wiley Online Library
DNA nanostructures have played an important role in the development of novel drug
delivery systems. Herein, we report a DNA origami‐based CRISPR/Cas9 gene editing …
delivery systems. Herein, we report a DNA origami‐based CRISPR/Cas9 gene editing …
Genetically encoded DNA origami for gene therapy in vivo
X Wu, C Yang, H Wang, X Lu, Y Shang… - Journal of the …, 2023 - ACS Publications
DNA origami has played an important role in various biomedical applications, including
biosensing, bioimaging, and drug delivery. However, the function of the long DNA scaffold …
biosensing, bioimaging, and drug delivery. However, the function of the long DNA scaffold …
Concept and development of framework nucleic acids
The blooming field of structural DNA nanotechnology harnessing the material properties of
nucleic acids has attracted widespread interest. The exploitation of the precise and …
nucleic acids has attracted widespread interest. The exploitation of the precise and …
A DNA-based nanocarrier for efficient gene delivery and combined cancer therapy
The efficient delivery of a therapeutic gene into target tissues has remained a major obstacle
in realizing a viable gene-based medicine. Herein, we introduce a facile and universal …
in realizing a viable gene-based medicine. Herein, we introduce a facile and universal …
Phase-separated biomolecular condensates for biocatalysis
Nature often uses dynamically assembling multienzymatic complexes called metabolons to
achieve spatiotemporal control of complex metabolic reactions. Researchers are aiming to …
achieve spatiotemporal control of complex metabolic reactions. Researchers are aiming to …