Functionalizing DNA origami to investigate and interact with biological systems

GA Knappe, EC Wamhoff, M Bathe - Nature Reviews Materials, 2023 - nature.com
DNA origami has emerged as a powerful method to generate DNA nanostructures with
dynamic properties and nanoscale control. These nanostructures enable complex …

Photocleavable Ortho-Nitrobenzyl-Protected DNA Architectures and Their Applications

MP O'Hagan, Z Duan, F Huang, S Laps, J Dong… - Chemical …, 2023 - ACS Publications
This review article introduces mechanistic aspects and applications of photochemically
deprotected ortho-nitrobenzyl (ONB)-functionalized nucleic acids and their impact on …

DNA origami: scaffolds for creating higher order structures

F Hong, F Zhang, Y Liu, H Yan - Chemical reviews, 2017 - ACS Publications
DNA has become one of the most extensively used molecular building blocks for
engineering self-assembling materials. DNA origami is a technique that uses hundreds of …

Biocatalytic cascades operating on macromolecular scaffolds and in confined environments

M Vázquez-González, C Wang, I Willner - Nature Catalysis, 2020 - nature.com
Biocatalytic cascades guide complex, efficient and selective intracellular transformations.
These unique features originate from the spatial organization of the biocatalysts in confined …

Building machines with DNA molecules

H Ramezani, H Dietz - Nature Reviews Genetics, 2020 - nature.com
In nature, DNA molecules carry the hereditary information. But DNA has physical and
chemical properties that make it attractive for uses beyond heredity. In this Review, we …

A DNA origami‐based gene editing system for efficient gene therapy in vivo

W Tang, T Tong, H Wang, X Lu, C Yang… - Angewandte Chemie …, 2023 - Wiley Online Library
DNA nanostructures have played an important role in the development of novel drug
delivery systems. Herein, we report a DNA origami‐based CRISPR/Cas9 gene editing …

Genetically encoded DNA origami for gene therapy in vivo

X Wu, C Yang, H Wang, X Lu, Y Shang… - Journal of the …, 2023 - ACS Publications
DNA origami has played an important role in various biomedical applications, including
biosensing, bioimaging, and drug delivery. However, the function of the long DNA scaffold …

Concept and development of framework nucleic acids

Z Ge, H Gu, Q Li, C Fan - Journal of the American Chemical …, 2018 - ACS Publications
The blooming field of structural DNA nanotechnology harnessing the material properties of
nucleic acids has attracted widespread interest. The exploitation of the precise and …

A DNA-based nanocarrier for efficient gene delivery and combined cancer therapy

J Liu, L Song, S Liu, Q Jiang, Q Liu, N Li, ZG Wang… - Nano Letters, 2018 - ACS Publications
The efficient delivery of a therapeutic gene into target tissues has remained a major obstacle
in realizing a viable gene-based medicine. Herein, we introduce a facile and universal …

Phase-separated biomolecular condensates for biocatalysis

S Lim, DS Clark - Trends in Biotechnology, 2024 - cell.com
Nature often uses dynamically assembling multienzymatic complexes called metabolons to
achieve spatiotemporal control of complex metabolic reactions. Researchers are aiming to …