Functionalizing DNA origami to investigate and interact with biological systems

GA Knappe, EC Wamhoff, M Bathe - Nature Reviews Materials, 2023 - nature.com
DNA origami has emerged as a powerful method to generate DNA nanostructures with
dynamic properties and nanoscale control. These nanostructures enable complex …

DNA origami: scaffolds for creating higher order structures

F Hong, F Zhang, Y Liu, H Yan - Chemical reviews, 2017 - ACS Publications
DNA has become one of the most extensively used molecular building blocks for
engineering self-assembling materials. DNA origami is a technique that uses hundreds of …

Building machines with DNA molecules

H Ramezani, H Dietz - Nature Reviews Genetics, 2020 - nature.com
In nature, DNA molecules carry the hereditary information. But DNA has physical and
chemical properties that make it attractive for uses beyond heredity. In this Review, we …

Biocatalytic cascades operating on macromolecular scaffolds and in confined environments

M Vázquez-González, C Wang, I Willner - Nature Catalysis, 2020 - nature.com
Biocatalytic cascades guide complex, efficient and selective intracellular transformations.
These unique features originate from the spatial organization of the biocatalysts in confined …

Photocleavable Ortho-Nitrobenzyl-Protected DNA Architectures and Their Applications

MP O'Hagan, Z Duan, F Huang, S Laps, J Dong… - Chemical …, 2023 - ACS Publications
This review article introduces mechanistic aspects and applications of photochemically
deprotected ortho-nitrobenzyl (ONB)-functionalized nucleic acids and their impact on …

Genetically encoded DNA origami for gene therapy in vivo

X Wu, C Yang, H Wang, X Lu, Y Shang… - Journal of the …, 2023 - ACS Publications
DNA origami has played an important role in various biomedical applications, including
biosensing, bioimaging, and drug delivery. However, the function of the long DNA scaffold …

Concept and development of framework nucleic acids

Z Ge, H Gu, Q Li, C Fan - Journal of the American Chemical …, 2018 - ACS Publications
The blooming field of structural DNA nanotechnology harnessing the material properties of
nucleic acids has attracted widespread interest. The exploitation of the precise and …

A DNA-based nanocarrier for efficient gene delivery and combined cancer therapy

J Liu, L Song, S Liu, Q Jiang, Q Liu, N Li, ZG Wang… - Nano Letters, 2018 - ACS Publications
The efficient delivery of a therapeutic gene into target tissues has remained a major obstacle
in realizing a viable gene-based medicine. Herein, we introduce a facile and universal …

From DNA nanotechnology to material systems engineering

Y Hu, CM Niemeyer - Advanced Materials, 2019 - Wiley Online Library
In the past 35 years, DNA nanotechnology has grown to a highly innovative and vibrant field
of research at the interface of chemistry, materials science, biotechnology, and …

Artificial Multienzyme Scaffolds: Pursuing in Vitro Substrate Channeling with an Overview of Current Progress

GA Ellis, WP Klein, G Lasarte-Aragones, M Thakur… - ACS …, 2019 - ACS Publications
Artificial multienzyme scaffolds are being developed for in vitro cascaded biocatalytic activity
and, in particular, accessing substrate channeling. This review covers progress in this field …