Transforming growth factor β signaling pathway: A promising therapeutic target for cancer

Y Chen, C Di, X Zhang, J Wang, F Wang… - Journal of cellular …, 2020 - Wiley Online Library
Transforming growth factor β (TGF‐β) is part of the transforming growth factor β superfamily
which is involved in many physiological processes and closely related to the …

NFAT as cancer target: mission possible?

JJ Qin, S Nag, W Wang, J Zhou, WD Zhang… - … Et Biophysica Acta (BBA …, 2014 - Elsevier
The NFAT signaling pathway regulates various aspects of cellular functions; NFAT acts as a
calcium sensor, integrating calcium signaling with other pathways involved in development …

HOXA13 is a potential GBM diagnostic marker and promotes glioma invasion by activating the Wnt and TGF-β pathways

R Duan, L Han, Q Wang, J Wei, L Chen, J Zhang… - …, 2015 - pmc.ncbi.nlm.nih.gov
Homeobox (HOX) genes, including HOXA13, are involved in human cancer. We found that
HOXA13 expression was associated with glioma grade and prognosis. Bioinformatics …

Viral myocarditis and dilated cardiomyopathy: etiology and pathogenesis

SA Huber - Current Pharmaceutical Design, 2016 - ingentaconnect.com
Myocarditis is an inflammation of the myocardium which often follows microbial infections
and is a significant cause of sudden unexpected death in the young (< 40 years of age) and …

microRNA-148a dysregulation discriminates poor prognosis of hepatocellular carcinoma in association with USP4 overexpression

MJ Heo, YM Kim, JH Koo, YM Yang, J An, SK Lee… - …, 2014 - pmc.ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is classified as a poor prognostic tumor, and becomes
frequently aggressive. MicroRNAs emerge as key contributors to tumor progression. This …

[HTML][HTML] NFAT signaling dysregulation in cancer: emerging roles in cancer stem cells

Y Lin, Y Song, Y Zhang, M Shi, A Hou, S Han - Biomedicine & …, 2023 - Elsevier
The nuclear factor of activated T cells (NFAT) was first identified as a transcriptional
regulator of activated T cells. The NFAT family is involved in the development of tumors …

RETRACTED: miR‐212/132 downregulates SMAD2 expression to suppress the G1/S phase transition of the cell cycle and the epithelial to mesenchymal transition in …

JL Zhao, L Zhang, X Guo, JH Wang, W Zhou, M Liu… - IUBMB …, 2015 - Wiley Online Library
MicroRNAs (miRNAs), a class of small noncoding RNAs that regulate target gene
expression, play an important role in cancer initiation, progression, and metastasis …

The D domain of LRRC4 anchors ERK1/2 in the cytoplasm and competitively inhibits MEK/ERK activation in glioma cells

Z Wang, Q Guo, R Wang, G Xu, P Li, Y Sun… - Journal of hematology & …, 2016 - Springer
Background As a well-characterized key player in various signal transduction networks,
extracellular-signal-regulated kinase (ERK1/2) has been widely implicated in the …

GP 73 promotes invasion and metastasis of bladder cancer by regulating the epithelial–mesenchymal transition through the TGF‐β1/Smad2 signalling pathway

HJ Yang, GL Liu, B Liu, T Liu - Journal of Cellular and …, 2018 - Wiley Online Library
This study investigated the effects of Golgi membrane protein 73 (GP 73) on the epithelial–
mesenchymal transition (EMT) and on bladder cancer cell invasion and metastasis through …

[HTML][HTML] Overexpression of miRNA-3613-3p enhances the sensitivity of triple negative breast cancer to CDK4/6 inhibitor palbociclib

Y Yu, H Liao, R **e, Y Zhang, R Zheng, J Chen… - Frontiers in …, 2020 - frontiersin.org
Triple negative breast cancer (TNBC) is characterized by lack of expression of the estrogen
and progesterone receptors and HER2, which are common therapeutic targets. CDK4/6 …