MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic
alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK) …

There is considerable evidence that chromosome structure plays important roles in gene
control, but we have limited understanding of the proteins that contribute to structural …

Accurate reconstruction of the regulatory networks that control gene expression is one of the
key current challenges in molecular biology. Although gene expression and chromatin state …

Pulmonary fibrosis is a chronic, progressive lung disease associated with lung damage and
scarring. The pathological mechanism causing pulmonary fibrosis remains unknown …

Abstract Cys2His2 (C2H2)-type zinc fingers are widespread DNA binding motifs in
eukaryotic transcription factors. Zinc fingers are short protein motifs composed of two or …

An increased DNA repair capacity is associated with drug resistance and limits the efficacy
of chemotherapy in breast cancers. Flap endonuclease 1 (FEN1) participates in various …

MITF governs multiple steps in the development of melanocytes, including specification from
neural crest, growth, survival, and terminal differentiation. In addition, the level of MITF …

ABSTRACT Yin Yang 1 (YY1) is a transcription factor with diverse and complex biological
functions. YY1 either activates or represses gene transcription, depending on the stimuli …

Humans are symbiotic organisms; our genome is populated with a substantial number of
endogenous retroviruses (ERVs), some remarkably intact, while others are remnants of their …