Phase-separating peptides (PSPs) self-assembling into coacervate microdroplets (CMs) are
a promising class of intracellular delivery vehicles that can release macromolecular …

The delivery of large molecules across biological barriers and into intracellular
environments is one of the grand challenges of biomedical research. The recent …

Liquid-liquid phase separation (LLPS) is a cornerstone of cellular organization, driving the
formation of biomolecular condensates that regulate diverse biological processes and …

A low-molecular-weight compound whose structure strikes a fine balance between
hydrophobicity and hydrophilicity may form coacervates via liquid–liquid phase separation …

Liquid–liquid phase separation (LLPS) of biomacromolecules is crucial for regulating
cellular functions. To explore their molecular mechanisms, peptide-based coacervates …

Cells contain membrane-bound and membraneless organelles that operate as spatially
distinct biochemical niches. However, these subcellular reaction centers lose fidelity with …

Coacervates have been investigated as protocells or synthetic cells, as well as subcellular
compartments for the creation of new materials, thus bridging the gap between living and …