The germinal centre (GC) response is critical for the generation of affinity-matured plasma
cells and memory B cells capable of mediating long-term protective immunity …

The current coronavirus pandemic (COVID-19), caused by SARS-CoV-2, has had
devastating effects on the global health and economic system. The cellular and molecular …

Severe SARS-CoV-2 infection has been associated with highly inflammatory immune
activation since the earliest days of the COVID-19 pandemic,,–. More recently, these …

While some infections elicit germinal centers, others produce only extrafollicular responses.
The mechanisms controlling these dichotomous fates are poorly understood. We identify IL …

Dysregulated immune responses against the SARS-CoV-2 virus are instrumental in severe
COVID-19. However, the immune signatures associated with immunopathology are poorly …

Summary Infection with SARS‐CoV‐2, the etiology of the ongoing COVID‐19 pandemic, has
resulted in over 450 million cases with more than 6 million deaths worldwide, causing global …

The widespread availability of single-cell RNA sequencing (scRNA-seq) has led to the
development of new methods for understanding immune responses. Single-cell …

High throughput sequencing of B cell receptors (BCRs) is increasingly applied to study the
immense diversity of antibodies. Learning biologically meaningful embeddings of BCR …

Protective immunity following vaccination is sustained by long-lived antibody-secreting cells
and resting memory B cells (MBCs). Responses to two-dose SARS-CoV-2 mRNA-1273 …

The clinical and immunological spectrum of acute and post-active COVID-19 syndrome
overlaps with criteria used to characterize autoimmune diseases such as rheumatoid …