Covering: 2013 to 2019 The exploration of the chemical diversity of extracts from various
biological sources has led to major drug discoveries. Over the past two decades, despite the …

Reversed-phase liquid chromatography (RPLC) is one of the most widely used
chromatographic approaches for the characterization of therapeutic proteins because it is …

Non-targeted and suspect analyses with liquid chromatography/electrospray/high-resolution
mass spectrometry (LC/ESI/HRMS) are gaining importance as they enable identification of …

Compound-specific stable isotope analysis (CSIA) is a unique analytical technique for
determining small variations in isotope ratios of light isotopes in analytes from complex …

LC/ESI/HRMS is increasingly employed for monitoring chemical pollutants in water samples,
with non-targeted analysis becoming more common. Unfortunately, due to the lack of …

Anthraquinones are the major bioactive compounds in alder buckthorn, a plant with a long
history of use for the treatment of obstipation in European and Asian traditional medicine. As …

The analysis of organic acids in complex mixtures by LC‐MS can often prove challenging,
especially due to the poor sensitivity of negative ionization mode required for detection of …

Purification of therapeutic monoclonal antibodies usually involves a protein A affinity capture
step. Because column breakthrough of antibody in complex, UV-absorbing culture fluid …

This study details the development of on-line two-dimensional liquid chromatography (2D-
LC) methods combining cation-exchange chromatography (CEX) and reversed-phase liquid …

Rationale Low‐molecular‐weight amines are encountered in pharmaceutical analysis, eg
as reactants in chemical syntheses, but are challenging to analyse using ultrahigh …