Cancer cell plasticity during tumor progression, metastasis and response to therapy

A Pérez-González, K Bévant, C Blanpain - Nature cancer, 2023‏ - nature.com
Cell plasticity represents the ability of cells to be reprogrammed and to change their fate and
identity, enabling homeostasis restoration and tissue regeneration following damage. Cell …

Cancers make their own luck: theories of cancer origins

A Jassim, EP Rahrmann, BD Simons… - Nature Reviews …, 2023‏ - nature.com
Cancer has been a leading cause of death for decades. This dismal statistic has increased
efforts to prevent the disease or to detect it early, when treatment is less invasive, relatively …

Cancer stem cells: Advances in knowledge and implications for cancer therapy

X Chu, W Tian, J Ning, G **ao, Y Zhou… - … and Targeted Therapy, 2024‏ - nature.com
Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy

M Chehelgerdi, F Behdarvand Dehkordi… - Molecular cancer, 2023‏ - Springer
The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia

AGX Zeng, S Bansal, L **, A Mitchell, WC Chen… - Nature medicine, 2022‏ - nature.com
The treatment landscape of acute myeloid leukemia (AML) is evolving, with promising
therapies entering clinical translation, yet patient responses remain heterogeneous, and …

Tumor microenvironment enriches the stemness features: the architectural event of therapy resistance and metastasis

P Nallasamy, RK Nimmakayala, S Parte, AC Are… - Molecular cancer, 2022‏ - Springer
Cancer divergence has many facets other than being considered a genetic term. It is a
tremendous challenge to understand the metastasis and therapy response in cancer …

Tumor-associated macrophages: an effective player of the tumor microenvironment

U Basak, T Sarkar, S Mukherjee… - Frontiers in …, 2023‏ - frontiersin.org
Cancer progression is primarily caused by interactions between transformed cells and the
components of the tumor microenvironment (TME). TAMs (tumor-associated macrophages) …

Leukemic stem cells and therapy resistance in acute myeloid leukemia

P Stelmach, A Trumpp - Haematologica, 2023‏ - pmc.ncbi.nlm.nih.gov
A major obstacle in the treatment of acute myeloid leukemia (AML) is refractory disease or
relapse after achieving remission. The latter arises from a few therapy-resistant cells within …

Photodynamic Therapy for the Treatment and Diagnosis of Cancer–A Review of the Current Clinical Status

G Gunaydin, ME Gedik, S Ayan - Frontiers in chemistry, 2021‏ - frontiersin.org
Photodynamic therapy (PDT) has been used as an anti-tumor treatment method for a long
time and photosensitizers (PS) can be used in various types of tumors. Originally, light is an …

Breast cancer: Biology, biomarkers, and treatments

K Barzaman, J Karami, Z Zarei, A Hosseinzadeh… - International …, 2020‏ - Elsevier
During the past recent years, various therapies emerged in the era of breast cancer. Breast
cancer is a heterogeneous disease in which genetic and environmental factors are involved …