Covering: July 2007 to June 2010. Previous review: Nat. Prod. Rep., 2009, 26, 382–445 A
great number of structurally diverse natural products containing five-membered heterocyclic …

Introduction: Hybrid anticancer drugs are of great therapeutic interests as they can
potentially overcome most of the pharmacokinetic drawbacks encountered when using …

Covering: 1964 to 2013 Natural products from bacteria and plants have played a leading
role in cancer drug discovery resulting in a large number of clinically useful agents. In …

Molecular Hybridization is an approach in rational drug design where new chemical entities
are obtained by combining two or more pharmacophoric units from different bioactive …

The review is devoted to the latest achievements in the design of dual action antibiotics—
heterodimeric (chimeric) structures based on antibacterial agents of different classes …

Inhibition of human carbonic anhydrase (hCA) isoform IX with concurrent induction of
apoptosis is a promising approach for targeting cancer in humans. Prompted by the scope …

The enantiospecific total synthesis of 14-membered macrolactone Sch 725674 was
accomplished from tartaric acid. Key reactions in the synthesis include the Ley's …

Syntheses of two 14-membered macrolides Sch-725674 and Gliomasolide C are described
here. The first total synthesis of Gliomasolide C, the short synthesis of Sch-725674, and …

This is a review of papers published in the year 2009 that focus on the synthesis, reactivity,
or properties of compounds containing a carbon-transition metal double or triple bond.

There are several challenges involved in the development of effective anti-cancer drugs,
including accurate drug delivery without toxic side effects. Possible systemic toxicity and the …