[HTML][HTML] Albumin-based delivery systems: Recent advances, challenges, and opportunities

G Murphy, DJ Brayden, DL Cheung, A Liew… - Journal of Controlled …, 2025 - Elsevier
Albumin and albumin-based biomaterials have been explored for various applications,
including therapeutic delivery, as therapeutic agents, as components of tissue adhesives …

Cocrystals and salts of milrinone with fluoro coformers: improving drug dissolution and diffusion and calculating normalized diffusion for pharmaceutical cocrystals

M Rana, A Garai, AK Nangia - Crystal Growth & Design, 2023 - ACS Publications
Milrinone (MRN) is a second-generation bipyridine phosphodiesterase inhibitor that
improves cardiac function and peripheral vasodilation in acute decongested heart failure …

Binary to ternary drug–drug molecular adducts of the antihypertensive drug ketanserin (KTS) with advanced physicochemical properties

SR Rout, G Kenguva, L Giri, A Kar… - Chemical …, 2023 - pubs.rsc.org
Focusing on a reliable supramolecular synthon approach, novel molecular salts of the
antihypertensive medication ketanserin (KTS) with aromatic carboxylic acid derivatives …

Multi-component forms of the 2nd generation H1 receptor antagonist drug, Bilastine and its enhanced physicochemical characteristics

A Kar, L Giri, G Kenguva, MK Bommaka, S Bandi… - Bioorganic …, 2024 - Elsevier
Bilastine (BIL) is a novel 2nd generation antihistamine medication is used to treat symptoms
of chronic urticaria and allergic rhinitis. However, its poor solubility limits its therapeutic …

Exploration of different solid variants of the anticancer medication Panobinostat (PNB) with improved physicochemical attributes

G Kenguva, L Giri, SR Rout, AN Acharya… - Journal of Molecular …, 2023 - Elsevier
Panobinostat (PNB), is a medication used for the treatment of multiple myeloma. It is a BCS
Class II drug with strong permeability and poor solubility. Therefore, it is highly desirable to …

Exploring novel cocrystals of milrinone: a cardioprotective drug combined with nutraceuticals and an NSAID

G Kenguva, SR Rout, TR Shaikh, D Baidya, N Shelke… - …, 2025 - pubs.rsc.org
Milrinone is a bipyridine phosphodiesterase (PDE) inhibitor of the second generation. It's a
PDE-III antagonist that raises cAMP levels to support heart function and acts as a systemic …

Synthesis, characterization and theoretical investigations of the newly developed molecular salts of an anti-psychotic drug (Penfluridol)

G Kenguva, SR Rout, A Kar, L Giri… - Journal of Molecular …, 2025 - Elsevier
Penfluridol (PEN) is a clinically relevant antipsychotic medication used to treat
schizophrenia; nevertheless, its bioavailability is limited due to its poor solubility. To address …

Structural insights into ketanserin salts with aliphatic acids and their physiochemical properties

G Kenguva, SR Rout, TR Shaikh, D Baidya, N Shelke… - …, 2024 - pubs.rsc.org
Ketanserin (KTS), a BCS class II drug, is used as an alpha-blocking serotonin antagonist.
The drug decreases blood pressure by lowering peripheral vascular resistance. In order to …

Mechanical approach for creating different molecular adducts and regulating salt polymorphs: a case study of the anti-inflammatory medication ensifentrine

A Kar, L Giri, G Kenguva, SR Rout… - RSC …, 2024 - pubs.rsc.org
An intriguing technique for crystal engineering is mechanochemistry, which frequently yields
various solid forms (salts, cocrystals, polymorphs, etc.) that are challenging to acquire using …

Novel molecular adducts of an anti-cancer drug vandetanib with enhanced solubility

RK Bandaru, L Giri, GR Krishna, R Dandela - CrystEngComm, 2024 - pubs.rsc.org
The solubility, permeability, and dissolution rate of an active pharmaceutical ingredient (API)
are critical factors in determining its pharmacokinetic performance in oral dosage forms …