Copper (Cu) is an essential element for humans and plants when present in lesser amount,
while in excessive amounts it exerts detrimental effects. There subsists a narrow difference …

Platinum-based anticancer drugs, including cisplatin, carboplatin, oxaliplatin, nedaplatin,
and lobaplatin, are heavily applied in chemotherapy regimens. However, the intrinsic or …

Copper (Cu) is a vital mineral essential for many biological processes. The vast majority of
all Cu in healthy humans is associated with enzyme prosthetic groups or bound to proteins …

Copper is one of the most abundant basic transition metals in the human body. It takes part
in oxygen metabolism, collagen synthesis, and skin pigmentation, maintaining the integrity …

Copper is an essential element in cells; it can act as either a recipient or a donor of
electrons, participating in various reactions. However, an excess of copper ions in cells is …

Chronic wounds are defined as wounds that fail to proceed through the normal phases of
wound healing in an orderly and timely manner. The most common and inevitable …

Copper is an important trace element that is required for essential enzymes. However, due
to its redox activity, copper can also lead to the generation of toxic reactive oxygen species …

Different strategies have been developed to overcome limitations of traditional
pharmacological treatments (biodegradation, low specificity, toxicity, side effects) …

Copper-containing enzymes perform fundamental functions by activating dioxygen (O 2) and
therefore allowing chemical energy-transfer for aerobic metabolism. The copper …

ATP7A and ATP7B, two homologous copper-transporting P1B-type ATPases, play crucial
roles in cellular copper homeostasis, and mutations cause Menkes and Wilson diseases …