The aggregation of specific proteins is hypothesized to underlie several degenerative
diseases, which are collectively known as amyloid disorders. However, the mechanistic …

Sickle cell disease is caused by an alteration in a single DNA base, but its clinical
manifestations are influenced by other genes and behavioral and environmental factors …

Background Sickle cell disease is characterized by hemolytic anemia, pain, and progressive
organ damage. A high level of erythrocyte fetal hemoglobin (HbF) comprising α-and γ …

MATERIALS AND METHODS Synthesis and Purification of Peptides. The peptides 026-39,
026-40, 026-42, and 026-43 were synthesized on the PAM resin using standard …

Alzheimer's disease (AD) is a neurodegenerative disease characterized by the presence of
cerebral amyloid plaque (reviewed by Selkoe, 1991), a highly ordered protein aggregate …

Although the root cause of sickle cell disease is the polymerization of hemoglobin S (HbS) to
form fibers that make red cells less flexible, most drugs currently being assessed in clinical …

In 1949, the discovery that sickle hemoglobin (α2 βS2) has an abnormal electrophoretic
mobility prompted Linus Pauling and his colleagues to christen sickle cell anemia “a …

The ability to relate bulk experimental measurements of amyloid formation to the
microscopic assembly processes that underlie protein aggregation is critical in order to …

Protein aggregation is an important phenomenon that alternatively is part of the normal
functioning of nature or, central to this review, has negative consequences via its …

Amyloids, fibrillar assembly of (poly) peptide chains, are associated with neurodegenerative
illnesses such as Alzheimer's and Parkinson's diseases, for which there are no cures. The …