The JNK signaling pathway in inflammatory skin disorders and cancer
The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a
subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide …
subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide …
Biological activity of berberine—A summary update
A Och, R Podgórski, R Nowak - Toxins, 2020 - mdpi.com
Berberine is a plant metabolite belonging to the group of isoquinoline alkaloids with strong
biological and pharmacological activity. Currently, berberine is receiving considerable …
biological and pharmacological activity. Currently, berberine is receiving considerable …
Comprehensive analysis of normal adjacent to tumor transcriptomes
Histologically normal tissue adjacent to the tumor (NAT) is commonly used as a control in
cancer studies. However, little is known about the transcriptomic profile of NAT, how it is …
cancer studies. However, little is known about the transcriptomic profile of NAT, how it is …
Hijacking of the AP-1 signaling pathway during development of ATL
Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of a fatal malignancy
known as adult T-cell leukemia (ATL). One way to address the pathology of the disease lies …
known as adult T-cell leukemia (ATL). One way to address the pathology of the disease lies …
Role of the transcription factor FOSL1 in organ development and tumorigenesis
VV Sobolev, AZ Khashukoeva, OE Evina… - International journal of …, 2022 - mdpi.com
The transcription factor FOSL1 plays an important role in cell differentiation and
tumorigenesis. Primarily, FOSL1 is crucial for the differentiation of several cell lineages …
tumorigenesis. Primarily, FOSL1 is crucial for the differentiation of several cell lineages …
New roles for AP-1/JUNB in cell cycle control and tumorigenic cell invasion via regulation of cyclin E1 and TGF-β2
B Pérez-Benavente, A Fathinajafabadi, L De la Fuente… - Genome Biology, 2022 - Springer
Background JUNB transcription factor contributes to the formation of the ubiquitous
transcriptional complex AP-1 involved in the control of many physiological and disease …
transcriptional complex AP-1 involved in the control of many physiological and disease …
Berberine, a herbal metabolite in the metabolic syndrome: The risk factors, course, and consequences of the disease
A Och, M Och, R Nowak, D Podgórska, R Podgórski - Molecules, 2022 - mdpi.com
In recent years, the health of patients exposed to the consequences of the metabolic
syndrome still requires the search for new solutions, and plant nutraceuticals are currently …
syndrome still requires the search for new solutions, and plant nutraceuticals are currently …
Allelic imbalance of chromatin accessibility in cancer identifies candidate causal risk variants and their mechanisms
While many germline cancer risk variants have been identified through genome-wide
association studies (GWAS), the mechanisms by which these variants operate remain …
association studies (GWAS), the mechanisms by which these variants operate remain …
Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic
Abstract Reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease (Ref-1/APE1) is a
critical node in tumor cells, both as a redox regulator of transcription factor activation and as …
critical node in tumor cells, both as a redox regulator of transcription factor activation and as …
AP-1 expression and its clinical relevance in immune disorders and cancer
S Trop-Steinberg, Y Azar - The American journal of the medical sciences, 2017 - Elsevier
The inflammatory response is known to have a significant role in certain autoimmune
diseases and malignancies. We review current knowledge regarding the functions of …
diseases and malignancies. We review current knowledge regarding the functions of …