Induced pluripotent stem cells (iPSCs) have entered an unprecedented state of
development since they were first generated. They have played a critical role in disease …

In recent years, significant biotechnological advancements have been made in engineering
human cardiac tissues and organ-like models. This field of research is crucial for both basic …

To reveal the three-dimensional microstructure and calcium dynamics of human heart
organoids (hHOs), we developed a dual-modality imaging system combining the …

Congenital heart defects constitute the most common birth defect in humans, affecting
approximately 1% of all live births. The incidence of congenital heart defects is exacerbated …

The use of human cardiac organoids (hCOs) as 3D in vitro models for cardiovascular
research has shown great promise. Human pluripotent stem cells (hPSCs) have proven to …

Cardiovascular diseases are currently the main cause of death. The study of the
pathogenesis and treatment of these diseases is still a major challenge. Traditional 2D …

A major limitation in studies aimed at investigating the molecular bases and pathogenetic
mechanisms in cardiac disease is the limited availability of cellular models capable of …