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Mechanisms and regulation of substrate degradation by the 26S proteasome
The 26S proteasome is involved in degrading and regulating the majority of proteins in
eukaryotic cells, which requires a sophisticated balance of specificity and promiscuity. In this …
eukaryotic cells, which requires a sophisticated balance of specificity and promiscuity. In this …
Structure, dynamics and function of the 26S proteasome
Y Mao - Macromolecular protein complexes III: Structure and …, 2021 - Springer
The 26S proteasome is the most complex ATP-dependent protease machinery, of~ 2.5 MDa
mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …
mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …
PSMC3 proteasome subunit variants are associated with neurodevelopmental delay and type I interferon production
A critical step in preserving protein homeostasis is the recognition, binding, unfolding, and
translocation of protein substrates by six AAA-ATPase proteasome subunits (ATPase …
translocation of protein substrates by six AAA-ATPase proteasome subunits (ATPase …
Proteasome substrate receptors and their therapeutic potential
The ubiquitin-proteasome system (UPS) is critical for protein quality control and regulating
protein lifespans. Following ubiquitination, UPS substrates bind multidomain receptors that …
protein lifespans. Following ubiquitination, UPS substrates bind multidomain receptors that …
Mechanisms of substrate recognition by the 26S proteasome
Highlights•Many types of ubiquitin modification can target proteins to the proteasome for
degradation.•The ubiquitin receptors of the RP individually and cooperatively function to …
degradation.•The ubiquitin receptors of the RP individually and cooperatively function to …
Proteasome interaction with ubiquitinated substrates: from mechanisms to therapies
The 26S proteasome is responsible for regulated proteolysis in eukaryotic cells. Its
substrates are diverse in structure, function, sequence length, and amino acid composition …
substrates are diverse in structure, function, sequence length, and amino acid composition …
[KNYGA][B] Macromolecular protein complexes III: structure and function
JR Harris, J Marles-Wright - 2021 - Springer
The compilation of this volume of the Subcellular Biochemistry series follows on from several
volumes already devoted to the Macromolecular Protein Complex theme. The present, and …
volumes already devoted to the Macromolecular Protein Complex theme. The present, and …
Ubiquitin modulates 26S proteasome conformational dynamics and promotes substrate degradation
The 26 S proteasome recognizes thousands of appropriate protein substrates in eukaryotic
cells through attached ubiquitin chains and uses its adenosine triphosphatase (ATPase) …
cells through attached ubiquitin chains and uses its adenosine triphosphatase (ATPase) …
Understanding the 26S proteasome molecular machine from a structural and conformational dynamics perspective
Highlights•New structures show the 26S proteasome with engaged substrate during ATP
hydrolysis.•The proteasomal Rpn11 is an essential, AAA+ motor-assisted deubiquitinase.• …
hydrolysis.•The proteasomal Rpn11 is an essential, AAA+ motor-assisted deubiquitinase.• …
Site-specific ubiquitination affects protein energetics and proteasomal degradation
Abstract Changes in the cellular environment modulate protein energy landscapes to drive
important biology, with consequences for signaling, allostery and other vital processes. The …
important biology, with consequences for signaling, allostery and other vital processes. The …