The 5-year survival rate in esophageal cancer, although poor, has improved over the past
decade. This review discusses the epidemiologic aspects, pathogenesis, prevention, and …

Mammalian organs are challenging to study as they are fairly inaccessible to experimental
manipulation and optical observation. Recent advances in three-dimensional (3D) culture …

ABSTRACT Three-dimensional (3D) cancer models are used as preclinical systems to
mimic physiologic drug responses. We provide evidence for strong changes of proliferation …

Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive squamous cell
carcinomas and is highly prevalent in Asia. Alcohol and its metabolite, acetaldehyde, are …

The tumor microenvironment (TME) plays a major role in the pathogenesis of multiple
cancer types, including upper-gastrointestinal (GI) cancers that currently lack effective …

The hallmarks of cancer are characterized by functional capabilities that allow cancer cells
to survive, proliferate and disseminate during the multistep tumorigenesis. Cancer being a …

Carcinoma-associated fibroblasts (CAFs) that express α-smooth muscle actin (αSMA)
contribute to cancer progression, but their precise origin and role are unclear. Using mouse …

Esophageal cancer is a deadly disease, ranking sixth among all cancers in mortality.
Despite incremental advances in diagnostics and therapeutics, esophageal cancer still …

The tumour suppressor p53 is known to prevent cancer progression by inhibiting
proliferation and inducing apoptosis of tumour cells. Slug, an invasion promoter, exerts its …

Background & Aims Despite recent progress in identifying aberrant genetic and epigenetic
alterations in esophageal squamous cell carcinoma (ESCC), the mechanism of ESCC …