Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
The brain requires a continuous supply of energy in the form of ATP, most of which is
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …
Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: Recent advances
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases,
characterized by impaired cognitive function due to progressive loss of neurons in the brain …
characterized by impaired cognitive function due to progressive loss of neurons in the brain …
Oxidative stress, synaptic dysfunction, and Alzheimer's disease
E Tönnies, E Trushina - Journal of Alzheimer's Disease, 2017 - content.iospress.com
Alzheimer's disease (AD) is a devastating neurodegenerative disorder without a cure. Most
AD cases are sporadic where age represents the greatest risk factor. Lack of understanding …
AD cases are sporadic where age represents the greatest risk factor. Lack of understanding …
The role of mitochondrial dysfunction in Alzheimer's disease pathogenesis
To promote new thinking of the pathogenesis of Alzheimer's disease (AD), we examine the
central role of mitochondrial dysfunction in AD. Pathologically, AD is characterized by …
central role of mitochondrial dysfunction in AD. Pathologically, AD is characterized by …
[HTML][HTML] Generation of reactive oxygen species by mitochondria
Reactive oxygen species (ROS) are series of chemical products originated from one or
several electron reductions of oxygen. ROS are involved in physiology and disease and can …
several electron reductions of oxygen. ROS are involved in physiology and disease and can …
Mitochondrial dysfunction and biogenesis in neurodegenerative diseases: pathogenesis and treatment
Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and
characterized by the progressive degeneration of the function and structure of the central …
characterized by the progressive degeneration of the function and structure of the central …
The putative Drp1 inhibitor mdivi-1 is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species
Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp1) is an
attractive drug target in numerous maladies that range from heart disease to …
attractive drug target in numerous maladies that range from heart disease to …
Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: an update on current advances and …
Neurodegenerative diseases (NDs) such as Alzheimer disease (AD), Parkinson disease
(PD), and Huntington disease (HD) represent a major socio-economic challenge in view of …
(PD), and Huntington disease (HD) represent a major socio-economic challenge in view of …
[HTML][HTML] Autophagy promotes cell survival by maintaining NAD levels
Autophagy is an essential catabolic process that promotes the clearance of surplus or
damaged intracellular components. Loss of autophagy in age-related human pathologies …
damaged intracellular components. Loss of autophagy in age-related human pathologies …
Multipronged diagnostic and therapeutic strategies for Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and a major
contributor to dementia cases worldwide. AD is clinically characterized by learning, memory …
contributor to dementia cases worldwide. AD is clinically characterized by learning, memory …