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Subcellular structure, heterogeneity, and plasticity of senescent cells
TC Bitencourt, JE Vargas, AO Silva, LR Fraga… - Aging …, 2024 - Wiley Online Library
Cellular senescence is a state of permanent growth arrest. It can be triggered by telomere
shortening (replicative senescence) or prematurely induced by stresses such as DNA …
shortening (replicative senescence) or prematurely induced by stresses such as DNA …
Nuclear morphology is a deep learning biomarker of cellular senescence
Cellular senescence is an important factor in aging and many age-related diseases, but
understanding its role in health is challenging due to the lack of exclusive or universal …
understanding its role in health is challenging due to the lack of exclusive or universal …
Efficient and reproducible generation of human iPSC-derived cardiomyocytes and cardiac organoids in stirred suspension systems
Human iPSC-derived cardiomyocytes (hiPSC-CMs) have proven invaluable for cardiac
disease modeling and regeneration. Challenges with quality, inter-batch consistency …
disease modeling and regeneration. Challenges with quality, inter-batch consistency …
Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practice
P Chen, Y Wang, B Zhou - Mechanisms of Ageing and Development, 2024 - Elsevier
Interconnected, fundamental aging processes are central to many illnesses and diseases.
Cellular senescence is a mechanism that halts the cell cycle in response to harmful stimuli …
Cellular senescence is a mechanism that halts the cell cycle in response to harmful stimuli …
Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes
Zika virus (ZIKV) has been extensively studied since it was linked to congenital
malformations, and recent research has revealed that astrocytes are targets of ZIKV …
malformations, and recent research has revealed that astrocytes are targets of ZIKV …
Damage-associated molecular patterns (DAMPs) related to immunogenic cell death are differentially triggered by clinically relevant chemotherapeutics in lung …
Background Chemotherapeutics can stimulate immune antitumor response by inducing
immunogenic cell death (ICD), which is activated by Damage-Associated Molecular Patterns …
immunogenic cell death (ICD), which is activated by Damage-Associated Molecular Patterns …
Comparison of cell behavior on pva/pva-gelatin electrospun nanofibers with random and aligned configuration
CY Huang, KH Hu, ZH Wei - Scientific reports, 2016 - nature.com
Electrospinning technique is able to create nanofibers with specific orientation. Poly (vinyl
alcohol)(PVA) have good mechanical stability but poor cell adhesion property due to the low …
alcohol)(PVA) have good mechanical stability but poor cell adhesion property due to the low …
Development of a functional glomerulus at the organ level on a chip to mimic hypertensive nephropathy
M Zhou, X Zhang, X Wen, T Wu, W Wang, M Yang… - Scientific reports, 2016 - nature.com
Glomerular hypertension is an important factor exacerbating glomerular diseases to end-
stage renal diseases because, ultimately, it results in glomerular sclerosis (especially in …
stage renal diseases because, ultimately, it results in glomerular sclerosis (especially in …
[HTML][HTML] Methoxyeugenol deactivates hepatic stellate cells and attenuates liver fibrosis and inflammation through a PPAR-ɣ and NF-kB mechanism
Ethnopharmacological relevance Studies have shown interest in nutraceuticals for the
prevention of liver diseases. Methoxyeugenol, is a molecule found in foods, such as nutmeg …
prevention of liver diseases. Methoxyeugenol, is a molecule found in foods, such as nutmeg …
High-throughput deconvolution of 3D organoid dynamics at cellular resolution for cancer pharmacology with Cellos
Abstract Three-dimensional (3D) organoid cultures are flexible systems to interrogate
cellular growth, morphology, multicellular spatial architecture, and cellular interactions in …
cellular growth, morphology, multicellular spatial architecture, and cellular interactions in …