Inflammation is a biological response involving immune cells, blood vessels and mediators
induced by endogenous and exogenous stimuli, such as pathogens, damaged cells or …

Recombination, together with mutation, generates the raw material of evolution, is essential
for reproduction and lies at the heart of all genetic analysis. Recent advances in our ability to …

Sex differences in overall recombination rates are well known, but little theoretical or
empirical attention has been given to how and why sexes differ in their recombination …

Meiotic recombination is required for the segregation of homologous chromosomes and is
essential for fertility. In most mammals, the DNA double-strand breaks (DSBs) that initiate …

To explore the link between DNA damage and gene silencing, we induced a DNA double-
strand break in the genome of Hela or mouse embryonic stem (ES) cells using I-SceI …

Combinatorial structure and algorithms for deducing genetic recombination history,
represented by ancestral recombination graphs and other networks, and their role in the …

Epidemiological studies have reported a higher incidence of rare disorders involving
imprinted genes among children conceived using assisted reproductive technology (ART) …

A comprehensive, domain-wide comparative analysis of genomic imprinting between
mammals that imprint and those that do not can provide valuable information about how and …

In many species, sex-related differences in crossover (CO) rates have been described at
chromosomal and regional levels. In this study, we determined the CO distribution along the …

The imprinted expression of the IGF2 and H19 genes is controlled by the imprinting control
region 1 (ICR1) located at chromosome 11p15. 5. This methylation-sensitive chromatin …