Therapeutic inhibition of the complement system in diseases of the central nervous system
SM Carpanini, M Torvell, BP Morgan - Frontiers in immunology, 2019 - frontiersin.org
The complement system plays critical roles in development, homeostasis, and regeneration
in the central nervous system (CNS) throughout life; however, complement dysregulation in …
in the central nervous system (CNS) throughout life; however, complement dysregulation in …
The hallmarks of P arkinson's disease
Since the discovery of dopamine as a neurotransmitter in the 1950s, P arkinson's disease
(PD) research has generated a rich and complex body of knowledge, revealing PD to be an …
(PD) research has generated a rich and complex body of knowledge, revealing PD to be an …
Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration
Previous studies demonstrate that intrastriatal injections of fibrillar alpha-synuclein (α-syn)
into mice induce Parkinson's disease (PD)-like Lewy body (LB) pathology formed by …
into mice induce Parkinson's disease (PD)-like Lewy body (LB) pathology formed by …
Neuroinflammation and oxidative stress: co-conspirators in the pathology of Parkinson's disease
Parkinson's disease (PD) is a complex disease, with genetics and environment contributing
to the disease onset. Recent studies of causative PD genes have confirmed the involvement …
to the disease onset. Recent studies of causative PD genes have confirmed the involvement …
Innate and adaptive immune responses in Parkinson's disease
Parkinson's disease (PD) has classically been defined as a movement disorder, in which
motor symptoms are explained by the aggregation of alpha-synuclein (α-syn) and …
motor symptoms are explained by the aggregation of alpha-synuclein (α-syn) and …
Animal models of Parkinson's disease: An updated overview
P Gubellini, P Kachidian - Revue neurologique, 2015 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder whose etiology,
besides a minority of genetic cases, is still largely unknown. Animal models have contributed …
besides a minority of genetic cases, is still largely unknown. Animal models have contributed …
Longitudinal in vivo metabolic labeling reveals tissue-specific mitochondrial proteome turnover rates and proteins selectively altered by parkin deficiency
KL Stauch, S Totusek, AJ Trease, LD Estrella… - Scientific reports, 2023 - nature.com
Our study utilizes a longitudinal isotopic metabolic labeling approach in vivo in combination
with organelle fraction proteomics to address the role of parkin in mitochondrial protein …
with organelle fraction proteomics to address the role of parkin in mitochondrial protein …
New developments in genetic rat models of Parkinson's disease
RB Creed, MS Goldberg - Movement Disorders, 2018 - Wiley Online Library
Preclinical research on Parkinson's disease has relied heavily on mouse and rat animal
models. Initially, PD animal models were generated primarily by chemical neurotoxins that …
models. Initially, PD animal models were generated primarily by chemical neurotoxins that …
The mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice
LJ Martin, S Semenkow, A Hanaford, M Wong - Neurobiology of aging, 2014 - Elsevier
Parkinson's disease (PD) is a movement disorder caused by neurodegeneration in
neocortex, substantia nigra and brainstem, and synucleinopathy. Some inherited PD is …
neocortex, substantia nigra and brainstem, and synucleinopathy. Some inherited PD is …
Strategies for manipulating microglia to determine their role in the healthy and diseased brain
B Parajuli, S Koizumi - Neurochemical Research, 2023 - Springer
Microglia are the specialized macrophages of the central nervous system and play an
important role in neural circuit development, modulating neurotransmission, and maintaining …
important role in neural circuit development, modulating neurotransmission, and maintaining …