[HTML][HTML] The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …
Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments
Z Yuan, Y Li, S Zhang, X Wang, H Dou, X Yu, Z Zhang… - Molecular cancer, 2023 - Springer
The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …
The updated landscape of tumor microenvironment and drug repurposing
Accumulating evidence shows that cellular and acellular components in tumor
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …
Tumor microenvironment complexity and therapeutic implications at a glance
R Baghban, L Roshangar… - Cell Communication and …, 2020 - Springer
The dynamic interactions of cancer cells with their microenvironment consisting of stromal
cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to …
cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to …
Targeting cancer stem cell pathways for cancer therapy
L Yang, P Shi, G Zhao, J Xu, W Peng, J Zhang… - Signal transduction and …, 2020 - nature.com
Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer
F Wu, J Yang, J Liu, Y Wang, J Mu, Q Zeng… - … and Targeted Therapy, 2021 - nature.com
To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …
Next-generation cancer organoids
Organotypic models of patient-specific tumours are revolutionizing our understanding of
cancer heterogeneity and its implications for personalized medicine. These advancements …
cancer heterogeneity and its implications for personalized medicine. These advancements …
Remodelling the extracellular matrix in development and disease
The extracellular matrix (ECM) is a highly dynamic structure that is present in all tissues and
continuously undergoes controlled remodelling. This process involves quantitative and …
continuously undergoes controlled remodelling. This process involves quantitative and …
Extracellular matrix structure
Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network
composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins …
composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins …
3D cell culture systems: tumor application, advantages, and disadvantages
O Habanjar, M Diab-Assaf, F Caldefie-Chezet… - International journal of …, 2021 - mdpi.com
The traditional two-dimensional (2D) in vitro cell culture system (on a flat support) has long
been used in cancer research. However, this system cannot be fully translated into clinical …
been used in cancer research. However, this system cannot be fully translated into clinical …