Unraveling biomarker signatures in triple-negative breast cancer: a systematic review for targeted approaches

P Pastena, H Perera, A Martinino, W Kartsonis… - International Journal of …, 2024‏ - mdpi.com
Triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast
cancer, marked by poor outcomes and dismal prognosis. Due to the absence of targetable …

ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation

Y Wu, C Zhang, X Liu, Z He, B Shan, Q Zeng… - Nature …, 2021‏ - nature.com
Cancer expression of PD-L1 suppresses anti-tumor immunity. PD-L1 has emerged as a
remarkable therapeutic target. However, the regulation of PD-L1 degradation is not …

Exosome-mediated miR-222 transferring: An insight into NF-κB-mediated breast cancer metastasis

J Ding, Z Xu, Y Zhang, C Tan, W Hu, M Wang… - Experimental cell …, 2018‏ - Elsevier
The subtypes of distant-organ metastasis led to treatment failure and poor prognosis are
major obstacles in the management of patients with advanced breast cancer (BCa) …

Single-Cell Transcriptome Profiling Reveals Intratumoral Heterogeneity and Molecular Features of Ductal Carcinoma In Situ

M Tokura, J Nakayama, M Prieto-Vila, S Shiino… - Cancer …, 2022‏ - aacrjournals.org
Ductal carcinoma in situ (DCIS) is a precursor to invasive breast cancer. The frequency of
DCIS is increasing because of routine mammography; however, the biological features and …

Detection of candidate biomarkers of prostate cancer progression in serum: a depletion-free 3D LC/MS quantitative proteomics pilot study

SET Larkin, HE Johnston, TR Jackson… - British journal of …, 2016‏ - nature.com
Background: Prostate cancer (PCa) is the most common male cancer in the United Kingdom
and we aimed to identify clinically relevant biomarkers corresponding to stage progression …

Chromothripsis in human breast cancer

M Bolkestein, JKL Wong, V Thewes, V Körber… - Cancer …, 2020‏ - aacrjournals.org
Chromothripsis is a form of genome instability by which a presumably single catastrophic
event generates extensive genomic rearrangements of one or a few chromosomes. Widely …

[HTML][HTML] Identification of niche-specific gene signatures between malignant tumor microenvironments by integrating single cell and spatial transcriptomics data

J Saqib, B Park, Y **, J Seo, J Mo, J Kim - Genes, 2023‏ - mdpi.com
The tumor microenvironment significantly affects the transcriptomic states of tumor cells.
Single-cell RNA sequencing (scRNA-seq) helps elucidate the transcriptomes of individual …