Chromophore based analyses of steady‐state diffuse reflectance spectroscopy: current status and perspectives for clinical adoption

TM Bydlon, R Nachabé, N Ramanujam… - Journal of …, 2015 - Wiley Online Library
Diffuse reflectance spectroscopy is a rapidly growing technology in the biophotonics
community where it has shown promise in its ability to classify different tissues. In the steady …

Optical spectroscopy: current advances and future applications in cancer diagnostics and therapy

DJ Evers, BHW Hendriks, GW Lucassen… - Future …, 2012 - Taylor & Francis
Optical spectroscopy (OS) is a tissue-sensing technique that could enhance cancer
diagnosis and treatment in the near future. With OS, tissue is illuminated with a selected light …

Nondestructive tissue analysis for ex vivo and in vivo cancer diagnosis using a handheld mass spectrometry system

J Zhang, J Rector, JQ Lin, JH Young, M Sans… - Science translational …, 2017 - science.org
Conventional methods for histopathologic tissue diagnosis are labor-and time-intensive and
can delay decision-making during diagnostic and therapeutic procedures. We report the …

Clinical study of noninvasive in vivo melanoma and nonmelanoma skin cancers using multimodal spectral diagnosis

L Lim, B Nichols, MR Migden… - … of biomedical optics, 2014 - spiedigitallibrary.org
The goal of this study was to determine the diagnostic capability of a multimodal spectral
diagnosis (SD) for in vivo noninvasive disease diagnosis of melanoma and nonmelanoma …

Probe pressure effects on human skin diffuse reflectance and fluorescence spectroscopy measurements

L Lim, B Nichols, N Rajaram… - Journal of biomedical …, 2011 - spiedigitallibrary.org
Diffuse reflectance and fluorescence spectroscopy are popular research techniques for
noninvasive disease diagnostics. Most systems include an optical fiber probe that transmits …

Endogenous and exogenous fluorescence skin cancer diagnostics for clinical applications

EG Borisova, LP Angelova… - IEEE Journal of Selected …, 2013 - ieeexplore.ieee.org
A short review will be presented of the recent clinical achievements in the field of skin
autofluorescence and exogenous fluorescence tumor detection. Photosensitizers used for …

Pilot clinical study for quantitative spectral diagnosis of non‐melanoma skin cancer

N Rajaram, JS Reichenberg… - Lasers in surgery …, 2010 - Wiley Online Library
Background Several research groups have demonstrated the non‐invasive diagnostic
potential of diffuse optical spectroscopy (DOS) and laser‐induced fluorescence (LIF) …

Design and characterization of a novel multimodal fiber-optic probe and spectroscopy system for skin cancer applications

M Sharma, E Marple, J Reichenberg… - Review of Scientific …, 2014 - pubs.aip.org
The design and characterization of an instrument combining Raman, fluorescence, and
reflectance spectroscopic modalities is presented. Instrument development has targeted skin …

Lookup-table method for imaging optical properties with structured illumination beyond the diffusion theory regime

TA Erickson, A Mazhar, D Cuccia… - … of biomedical optics, 2010 - spiedigitallibrary.org
Sinusoidally structured illumination is used in concert with a phantom-based lookup-table
(LUT) to map wide-field optical properties in turbid media with reduced albedos as low as …

Experimental validation of the effects of microvasculature pigment packaging on in vivo diffuse reflectance spectroscopy

N Rajaram, A Gopal, X Zhang… - Lasers in surgery and …, 2010 - Wiley Online Library
Background Diffuse reflectance spectroscopy (DRS) uses the steady‐state diffuse
reflectance measured from the tissue surface to determine absorption and scattering …